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Intravascular lymphomatosis: a clinicopathological study of two cases presenting as an interstitial lung disease

Authors
 Y.H.KO  ;  J.H.HAN  ;  J.H.GO  ;  D.S.KIM  ;  O.J.KWON  ;  W.I.YANG  ;  D.H.SHIN  ;  H.J.REE 
Citation
 HISTOPATHOLOGY, Vol.31(6) : 555-562, 1997 
Journal Title
 HISTOPATHOLOGY 
ISSN
 0309-0167 
Issue Date
1997
MeSH
Aged ; Diagnosis, Differential ; Humans ; Lung Diseases, Interstitial/diagnosis* ; Lung Diseases, Interstitial/pathology ; Lung Neoplasms/blood supply ; Lung Neoplasms/diagnosis* ; Lung Neoplasms/pathology ; Lymphoma, Non-Hodgkin/diagnosis* ; Lymphoma, Non-Hodgkin/pathology ; Male ; Middle Aged
Abstract
AIMS: Intravascular lymphomatosis is an uncommon type of non-Hodgkin's lymphoma characterized by intravascular proliferation of neoplastic lymphoid cells. Although the tumour is basically a systemic disease, eventually involving multiple organs, primary presentation in the lung is rare. METHODS AND RESULTS: We describe the clinicopathological features of two patients with intravascular lymphomatosis presenting in the lung. One patient complained of fever, headache and chest pain; the other, of dyspnoea on exertion and headache. Both patients showed reticulonodular density on chest radiography and decreased diffusion capacity. Lung biopsy showed features characteristic of intravascular lymphomatosis. Malignant lymphoid cells were CD30 positive T-cells of anaplastic large cell type in one patient and B-cells of large cell type in the other. There was a poor response to chemotherapy and both patients died of the disease within 3 months of diagnosis. CONCLUSIONS: These cases and 10 previous reports illustrate the need to include intravascular lymphomatosis in the differential diagnosis of interstitial lung disease.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2559.1997.3310898.x?sid=nlm%3Apubmed
DOI
10.1046/j.1365-2559.1997.3310898.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177303
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