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Sequential production and activation of matrix-metalloproteinase-9 (MMP-9) with breast cancer progression

Authors
 Sun Young Rha  ;  Joo Hang Kim  ;  Jae Kyung Roh  ;  Kyong Sik Lee  ;  Jin Sik Min  ;  Byung Soo Kim  ;  Hyun Cheol Chung 
Citation
 BREAST CANCER RESEARCH AND TREATMENT, Vol.43(2) : 175-181, 1997 
Journal Title
 BREAST CANCER RESEARCH AND TREATMENT 
ISSN
 0167-6806 
Issue Date
1997
MeSH
Breast Neoplasms/enzymology* ; Breast Neoplasms/pathology* ; Collagenases/biosynthesis* ; Collagenases/metabolism* ; Disease Progression ; Enzyme Activation ; Humans ; Matrix Metalloproteinase 9
Abstract
The degradation of the basement membrane by matrix-metalloproteinase (MMP) and serine protease is a critical point in tumor invasion and metastasis. We measured the activity of MMP-9 from 28 normal, 12 benign and 126 breast cancer tissues using gelatin zymography with an image analysis system. ProMMP-9 was expressed in 17.5% of the cancer patients compared to 2.5% in 40 non-cancerous tissues (p = 0.014). The mature form of MMP-9 (82 kD) was expressed only in T2-T4 stages. During the early phase of breast cancer (DCIS and T1 stage) progression, only production of proMMP-9 increased. However, as the cancer grew or invaded skin (T2-T4), or with lymphovascular permeation, both production and activation of MMP-9 increased. In conclusion, proMMP-9 production was the main cause of increased MMP-9 activity during the early phase, while both production and activation increased in the late phase of breast cancer.
Full Text
https://link.springer.com/article/10.1023/a%3A1005701231871
DOI
10.1023/a:1005701231871
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177272
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