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P-glycoprotein: The intermediate end point of drug response to induction chemotherapy in locally advanced breast cancer

Authors
 Hyun Cheol Chung  ;  Sun Young Rha  ;  Joo Hang Kim  ;  Jae Kyung Roh  ;  Jin Sik Min  ;  Kyung Sik Lee  ;  Byung Soo Kim  ;  Kyi Beom Lee 
Citation
 BREAST CANCER RESEARCH AND TREATMENT, Vol.42(1) : 65-72, 1997 
Journal Title
 BREAST CANCER RESEARCH AND TREATMENT 
ISSN
 0167-6806 
Issue Date
1997
MeSH
ATP Binding Cassette Transporter, Subfamily B, Member 1/biosynthesis* ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Breast Neoplasms/drug therapy* ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/drug therapy* ; Carcinoma, Ductal, Breast/metabolism ; Carcinoma, Ductal, Breast/pathology ; Chemotherapy, Adjuvant ; Cyclophosphamide/administration & dosage ; Doxorubicin/administration & dosage ; Drug Resistance, Multiple* ; Drug Resistance, Neoplasm ; Female ; Fluorouracil/administration & dosage ; Humans ; Immunohistochemistry ; Male ; Middle Aged
Abstract
Expression and clinical relevance of p-glycoprotein (p-gp) were evaluated in 31 cases of locally advanced breast cancer and 9 cases involving inflammatory breast cancer after induction chemotherapy. The de novo p-gp expression rate was 26% and increased up to 58% (p = 0.03) with the FAC (5-fluorouracil, adriamycin, cyclophosphamide) regimen. Although more clinically complete responders were found in the secondary p-gp negative group (p = 0.02), this difference was not found in pathological tumor response. Moreover, as the grade of the secondary p-gp expression increased, the chemotherapeutic effect decreased, suggesting an inverse relationship between p-gp expression and drug effect (p = 0.04). When we subgrouped the patients into 4 groups using these two parameters, p-gp negative patients presenting with a high drug effect showed a low recurrence rate (p = 0.05) and marginal survival benefits (p = 0.09) as opposed to patients with a low drug effect. But in p-gp positive groups, the recurrence rate was the same between the two groups regardless of the drug effect. Thus, in the p-gp negative patient with a high drug effect, adjuvant chemotherapy with the same regimen as induction chemotherapy may induce more prognostically favorable results. Therefore, clinical application of the secondary p-gp detection can be used as an intermediate endpoint in evaluating drug response for an induction regimen.
Full Text
https://link.springer.com/article/10.1023/a%3A1005739525196
DOI
10.1023/a:1005739525196
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177270
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