0 23

Cited 0 times in

Seasonal variation of skin reactivity and specificIgE antibody to house dust mite

Authors
 Dong-Ho Nahm  ;  Hae-Sim Park  ;  Soeng-Sook Kang  ;  Chein-Soo Hong 
Citation
 ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Vol.78(6) : 589-593, 1997 
Journal Title
 ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 
ISSN
 1081-1206 
Issue Date
1997
MeSH
Adolescent ; Adult ; Allergens/immunology ; Animals ; Antibody Specificity ; Antigens, Dermatophagoides ; Asthma/immunology ; Female ; Glycoproteins/immunology* ; Humans ; Immunoglobulin E/blood ; Immunoglobulin E/immunology* ; Male ; Mites/immunology ; Seasons* ; Skin/immunology* ; Skin Tests
Abstract
BACKGROUND: House dust mite is an important cause of bronchial asthma worldwide. While the allergen is present all year-round, a seasonal variation of house dust mite allergen levels has been found. There have been few reports, however, on seasonal variation of specific immune response to house dust mite. OBJECTIVE: We studied the changes in skin reactivity and specific IgE antibody to house dust mite associated with seasonal variation of house dust mite allergen levels in houses of mite-sensitive asthmatic patients. METHODS: In 14 mite-sensitive asthmatic patients, house dust mite allergen (Der f 1) contents in bedding were measured monthly. Skin reactivity on prick test and specific IgE antibody to house dust mite, Dermatophagoides farinae (D. farinae), were determined every 3 months from july to December. RESULTS: The concentration of Der f 1 in dust from bedding reached maximum levels in August and September, and significantly decreased in November and December compared with August and September (P < .05). Skin reactivity (a ratio of mean wheal diameter of allergen to histamine) to D. farinae decreased significantly in December compared with September (P < .05). Serum levels of total IgE and specific IgE antibody to D. farinae decreased significantly in December compared with September (P < .05). CONCLUSION: These findings suggest that seasonal changes in natural exposure to house dust mite allergen might lead to concurrent changes in skin reactivity and specific IgE antibody to house dust mite in mite-sensitive asthmatic patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S1081120610632218?via%3Dihub
DOI
10.1016/S1081-1206(10)63221-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177258
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links