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A Comparative Study of Intravenous Granisetron Versus Intravenous and Oral Ondansetron in the Prevention of Nausea and Vomiting Associated with Moderately Emetogenic Chemotherapy

 Park JO  ;  Rha SY  ;  Yoo NC  ;  Kim JH  ;  Roh JK  ;  Min JS  ;  Kim BS  ;  Chung HC 
 American Journal of Clinical Oncology, Vol.20(6) : 569-572, 1997 
Journal Title
 American Journal of Clinical Oncology 
Issue Date
Administration, Oral ; Adult ; Aged ; Antiemetics/administration & dosage ; Antiemetics/therapeutic use* ; Antineoplastic Agents/adverse effects ; Drug Administration Schedule ; Female ; Granisetron/administration & dosage ; Granisetron/therapeutic use* ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Nausea/chemically induced ; Nausea/prevention & control* ; Ondansetron/administration & dosage ; Ondansetron/therapeutic use* ; Prospective Studies ; Vomiting/chemically induced ; Vomiting/prevention & control*
We conducted a prospective, randomized, open, single-center, parallel group study comparing the anti-emetic efficacy and toxicity of granisetron with that of ondansetron in patients receiving moderately emetogenic chemotherapy. From December 1994 to May 1995, patients who were to receive moderately emetogenic chemotherapy for the first time or who had not received chemotherapy (80 to 100 mg/m2 of cisplatin or 40 mg/m2 of doxorubicin) within 4 weeks previously were enrolled in this study. The following anti-emetic regimens were used: 3 mg of granisetron were given intravenously before chemotherapy for a single dose; 8 mg of ondansetron were given intravenously before chemotherapy and then every 8 hours for a total of 3 doses, plus 8 mg of an oral maintenance dose every 12 hours for 5 consecutive days. We evaluated 97 patients (48 received granisetron and 49 received ondansetron). In the first 24 hours after chemotherapy, complete and major responses were achieved in 76.6% of the patients receiving granisetron and in 72.9% of patients receiving ondansetron (p = 0.9033). Additionally, there was no difference in the control of delayed nausea and vomiting between the two groups (51.1% versus 54.2%, p = 0.9200), and there were no significant adverse effects or toxicities. We have concluded that a single dose of granisetron is as effective in prophylaxis of emesis induced by moderately emetogenic chemotherapy as a triple dose of ondansetron plus oral maintenance.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
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