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Seasonal variation of IgG subclass antibodies to house dust mite in sera from mite-sensitive asthmatic patients

Authors
 Dong-Ho Nahm  ;  Hae-Sim Park  ;  Cheol-Woo Kim  ;  Jung-Won Park  ;  Chein-Soo Hong 
Citation
 ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Vol.80(5) : 411-415, 1998 
Journal Title
 ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 
ISSN
 1081-1206 
Issue Date
1998
MeSH
Adolescent ; Adult ; Animals ; Antibodies/classification* ; Asthma/immunology* ; Dust ; Female ; Humans ; Immunoglobulin G/classification* ; Male ; Mites/immunology* ; Seasons*
Abstract
BACKGROUND: House dust mite is an important cause of bronchial asthma. Seasonal variation of environmental house dust mite allergen levels and the specific IgE antibody to house dust mite have been reported. OBJECTIVE: We studied the changes in IgG subclass antibodies to house dust mite associated with seasonal variation of house dust mite allergen levels in houses of mite-sensitive asthmatic patients. METHODS: In 14 mite-sensitive asthmatic patients, house dust mite allergen (Der f 1) contents in bedding were measured monthly, and IgG subclass antibodies to house dust mite, Dermatophagoides farinae (D. farinae), were determined by enzyme-linked immunosorbent assay (ELISA) every 3 months from July to December. RESULTS: The concentration of Der f 1 in dust from bedding reached maximum levels in August and September, and significantly decreased in November and December compared with August and September (P < .05). Levels of D. farinae-specific IgG4 antibodies significantly decreased in December compared with September (P < .05) with no statistically significant change between September and June (P > .05). Levels of D. farinae-specific IgG2 antibodies decreased significantly in December compared with June (P < .05). The levels of IgG1 and IgG3 antibodies to D. farinae showed no significant differences during the study period. CONCLUSION: These findings suggest that seasonal changes in natural exposure to house dust mite allergen might lead to concurrent changes in specific IgG4 antibodies to house dust mite in mite-sensitive asthmatic patients and each IgG subclass antibodies to house dust mite might have a different kinetics.
Full Text
https://www.sciencedirect.com/science/article/pii/S1081120610629936
DOI
10.1016/s1081-1206(10)62993-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177133
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