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흰쥐 난소내 Leptin 및 Leptin 수용체의 발현

Other Titles
 Expression of Leptin and Its Receptor in Rat Ovary 
Authors
 김명신  ;  양현원  ;  권혁찬  ;  황경주  ;  윤현숙  ;  박금자  ;  김세광  ;  윤용달 
Citation
 Development & Reproduction (발생과 생식), Vol.2(2) : 173-178, 1998 
Journal Title
 Development & Reproduction (발생과 생식) 
ISSN
 1226-6752 
Issue Date
1998
Abstract
Leptin, the product of the obese gene, is produced by adipose tissue and is known to be a hormone concerned with regulation of appetite and metabolism. Recent reports have shown that leptin is associated not only with obesity but also with female reproduction, but it has not yet been ascertained whether leptin acts directly on the ovaries or indirectly via the hypothalamus or pituitary pathway. The object of this study is to determine the expression of leptin and its receptor in the ovaries of 3 and 8 weeks old rats by immunohistochemistry and RT-PCR. In the ovaries of 3 and 8 weeks old rats, leptin was stained in the theca cells and portions of granulosa cells of atretic follicles, whereas leptin receptors was stained in interstitial cells and ova of preantral follicles. The RT-PCR results showed that leptin receptor mRNA was expressed in the ovaries of both immature and adult rats, while leptin mRNA was not. In conclusion, leptin mRNA was not expressed in the ovaries, however, leptin was detected by immunohistochemistry. Compared to leptin itself, leptin receptors in the ovaries were ascertained by both RT-PCR and immunohistochemistry. These results suggest that leptin is related to the regulation of the physiological functions of the ovaries.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sei Kwang(김세광)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177115
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