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Plasmid-encoded AmpC β-lactamases: how far have we gone 10 years after the discovery?

Authors
 Adolf Bauernfeind  ;  Yunsop Chong  ;  Kyungwon Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.39(6) : 520-525, 1998 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
1998
MeSH
Bacterial Proteins* ; Microbiology/trends ; Plasmids/genetics* ; Structure-Activity Relationship ; Tissue Distribution ; beta-Lactamases/genetics* ; beta-Lactamases/metabolism
Abstract
The dogma that ampC genes are located exclusively on the chromosome was dominant until about 10 years ago. Since 1989 over 15 different plasmid-encoded AmpC β-lactamases have been reported from several countries. Most of these enzymes evolved in two clusters. The major cluster includes several enzymes with a high similarity to CMY-2, which is the closest related chromosomal AmpC enzyme of Citrobacter freundii. A second cluster centers around CMY-1. It is less homogeneous and not closely related chromosomal AmpC enzymes. Molecular diversification by amino acid substitutions does not usually translate into a change in the resistance phenotype. At this time, CMY-2 appears to be the most prevalent and widely distributed. Further global increase of prevalence and diversity of plasmidic AmpC β-lactamases have to be anticipated in the next millenium.
Files in This Item:
T199803236.pdf Download
DOI
10.3349/ymj.1998.39.6.520
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177102
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