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급성 거부 반응이 이식신의 장기 생존율에 미치는 영향

Other Titles
 The Impact of Acute Rejection on Long-Term Graft Outcome in Renal Allograft Recipient 
 문장일  ;  이창목  ;  김순일  ;  김명수  ;  김유선  ;  박기일 
 Journal of the Korean Society for Transplantation, Vol.12(1) : 1-7, 1998 
Journal Title
Journal of the Korean Society for Transplantation(대한이식학회지)
Issue Date
Acute rejection after renal transplantation is still the most common cause of graft failure during the early post-transplant period. To determine whether an acute rejection episode adversely affects long-term graft survival, we retrospectively analyzed our single center patients population of 1266 consecutive living donor kidney transplantations performed between April 1984 and October 1995. Five hundred twenty three recipients(41.3%) experienced 711 acute rejection episodes. Among these 711 episodes, 92.6% were respond to anti-rejection therapy and treatment failure rate was 7.6%. Late onset acute rejection, which developed 1 year after transplantation, showed poor treatment response(79.7%). There was statistically significant difference of graft survival rate between acute rejection free group and acute rejection group. Furthermore, the frequency of acute rejection, response rate the steroid pulse therapy and the degree f remission affected the graft survival rate. Donor source impacted on the development of acute rejection-33.1% in living related donor, 39.9% in living unrelated donor and 57.1% in cadaveric donor transplantation. In living related donor kidney transplantations, HLA identical pairs(11%) showed less acute rejection episodes than HLA haplo-identical pairs(38.7%). In living unrelated donor kidney transplantations, HLA antigen match adversely affected the acute rejection rate-43.9%, 35.8% and 30.6% in 1 ∼2, 3 and 4~5 Ag match group, respectively. ABO blood group compatibility, recipient` s age and compatibility of HLA DR Ag did not influenced to the development of acute rejection. These results suggest that the acute rejection could be a major determinant of long-term graft outcome.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
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