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유전자재조합 인형 과립구집락촉진인자(rhG-CSF)에 의한 Ticlopidine유도 호구중 감소증 치험 1예

Other Titles
 A Case of Ticlopidine-induced Neutropenia Treated with rhG-CSF 
 이상길  ;  안철우  ;  김현수  ;  임세중  ;  조승연  ;  민유홍 
 Korean Circulation Journal (순환기), Vol.28(1) : 118-122, 1998 
Journal Title
 Korean Circulation Journal (순환기) 
Issue Date
There are many conditions which are associated with neutropenia, such as infections, chemical and physical agents, and hematopoietic diseases. But ticlopidine-induced neutropenis is rarely reported in Korea. We experienced a case of neutropenia which developed after approximately 1 month of ticlopidine administrarion to a stable angina pectories patient. A 59 year-old woman with stable angina pectoris was placed on ticlopidine. Forty days later, she was admitted for high fevers and shaking chills. On admission, leukocyte count was 900/mm (3) (neutrophil 0/mm (3)), hemoglobin was 11.8g/dl, and platelet count was 440.000/mm (3). After confirming ticlopidine-induced neutropenia by bone marrow aspiration and biopsy, we administated rhG-CSF (neutrogen (r), Choongwae. Co. Korea) at a dose of 3-5ug/kg daily. On the 25th day of treatment, leukocyte count reached 2,890/mm (3). She experienced no adverse effects of rhG-CSF treatment and recorved completely. We assume that the rapid recovery of granulocytes was attributable to rhG-CSF, and we suggest that rhG-CSF should be tried in a patients with ticlopidine-induced neutropenia with depletion of myeloid precursors in the hypocelluar bone marrow.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
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