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The effect of botulinum toxin type A injection for intrinsic rhinitis

Authors
 Kyung-Su Kim  ;  Sung-Shik Kim  ;  Joo-Heon Yoon  ;  Jae Wook Han 
Citation
 JOURNAL OF LARYNGOLOGY AND OTOLOGY, Vol.112(3) : 248-251, 1998 
Journal Title
 JOURNAL OF LARYNGOLOGY AND OTOLOGY 
ISSN
 0022-2151 
Issue Date
1998
MeSH
Adult ; Botulinum Toxins, Type A/administration & dosage ; Botulinum Toxins, Type A/therapeutic use* ; Cholinergic Antagonists/therapeutic use* ; Double-Blind Method ; Female ; Humans ; Injections ; Male ; Middle Aged ; Nasal Septum ; Rhinitis/drug therapy* ; Statistics, Nonparametric
Abstract
Botulinum toxin type A (BTA) is known to inhibit the release of acetylcholine from cholinergic nerve endings. Owing to the characteristics of BTA, we thought that it could be used for the treatment of intrinsic rhinitis acting as an anticholinergic drug. In a double-blind placebo-controlled study four units of BTA were injected into the middle turbinate (two units) and inferior turbinate (two units) in each nasal cavity. Rhinorrhoea, nasal obstruction, and sneezing were recorded in a symptom diary on the basis of a scale of 5 and the number of paper tissues used per day was also recorded for 24 weeks. Rhinorrhoea was significantly diminished in severity (24.1-41.5 per cent reduction) and paper tissue use (54.3 per cent reduction) in the BTA group compared with the placebo group. This effect could be maintained for four weeks. Sneezing and nasal stuffiness were not affected by BTA. These results suggest that BTA can be used to treat rhinorrhoea in intrinsic rhinitis patients, however, the effective period is short.
Full Text
https://www.cambridge.org/core/journals/journal-of-laryngology-and-otology/article/effect-of-botulinum-toxin-type-a-injection-for-intrinsic-rhinitis/9859EBCEC4F92E5328AF6AC198F8A9B7
DOI
10.1017/s0022215100158281
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Yoon, Joo Heon(윤주헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177041
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