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Cell proliferation index and the expression of p53 and bcl-2 in tumorous and non-tumorous lesions of hepatocellular carcinoma and metastatic liver cancer.

 Dong Sup Yoon  ;  Jae Ho Cheong  ;  Young Nyun Park  ;  Sung Won Kwon  ;  Hoon Sang Chi  ;  Byong Ro Kim 
 YONSEI MEDICAL JOURNAL, Vol.39(5) : 424-429, 1998 
Journal Title
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Adult ; Aged ; Carcinoma, Hepatocellular/metabolism* ; Carcinoma, Hepatocellular/pathology* ; Cell Division/physiology ; Female ; Humans ; Liver Neoplasms/metabolism* ; Liver Neoplasms/pathology* ; Liver Neoplasms/secondary ; Male ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/metabolism* ; Tumor Suppressor Protein p53/metabolism*
In the development of a cancer, unlimited cell proliferation has been believed to play an important role. In addition, a programmed cell death called apoptosis, which is regulated by several oncogenes and tumor suppressor genes, has been suggested to be another important different pathway of carcinogenesis. Recently, several reports on cell proliferation capacity and apoptosis in the development of human liver disease have been published, but the cell proliferation index and its relationship between the expression of the bcl-2 and p53 genes involving apoptosis has not yet been discussed in view of the clinical differences of primary and metastatic liver cancer. In this study, we investigated the cell proliferation index and expression of p53 and bcl-2 in the tumorous and non-tumorous portions of both hepatocellular carcinoma and metastatic liver cancer. The expression of p53 was observed in both hepatocellular carcinoma and metastatic liver cancer, but bcl-2 expression was observed neither in hepatocellular carcinoma nor in metastatic liver cancer. In hepatocellular carcinoma, the p53 positive group showed a higher Ki-67 score (cell proliferation index) and more tumor numbers than the p53 negative group (p<0.05). In metastatic liver cancer, the results were the same as in hepatocellular carcinoma (p<0.05). However, we could not correlate the p53 expression and its prognostic significance in hepatocellular carcinoma.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
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