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Phylogenetic analysis of the nef gene reveals a distinctive monophyletic clade in Korean HIV-1 cases

Authors
 Mi Ran Kang  ;  Young-Keol Cho  ;  Jongsik Chun  ;  Young-Bong Kim  ;  Im-Soon Lee  ;  Hee Jung Lee  ;  Seon Hee Kim  ;  Yoo-Kyum Kim  ;  Keejung Yoon  ;  Jai-Myung Yang  ;  June Myung Kim  ;  Yung-Oh Shin  ;  Chun Kang  ;  Joo Shil Lee  ;  Kang Won Choi  ;  Dae-Ghon Kim  ;  Walter M. Fitch  ;  Sunyoung Kim 
Citation
 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.17(1) : 58-68, 1998 
Journal Title
 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 
ISSN
 1525-4135 
Issue Date
1998
MeSH
Adolescent ; Adult ; Amino Acid Sequence ; Child ; Child, Preschool ; Cloning, Molecular ; Genes, nef* ; Genetic Variation ; HIV Infections/epidemiology ; HIV Infections/virology* ; HIV-1/classification* ; HIV-1/genetics* ; Humans ; Korea/epidemiology ; Male ; Molecular Sequence Data ; Phylogeny ; Sequence Alignment ; Sequence Analysis, DNA
Abstract
To study the genetic variation of the HIV-1 strains prevalent in South Korea, we analyzed the nef sequences derived from 46 HIV-1-positive individuals living in various geographic regions in Korea. Phylogenetic analysis revealed four subtypes of HIV-1: A (3 patients), B (41 patients), D (1 patient), and a type that could not be clearly classified to any known subtype (1 patient). Thirty-five of the 41 Korean subtype B isolates formed a distinct monophyletic clade that is not related to any of the international sequences from the Los Alamos Database or GenBank as of June 1997. Indeed, the presence of unique conserved sequences was identified among the Korean isolates in this Korean subtype B group. The variations in the nucleotide sequences of a majority (32 of 35) subtype B samples within the Korean clade were 1.9% to 8.8%, and amino acid sequences varied from 3.9% to 15.5%. These results suggest that HIV-1 strains currently present in South Korea might have originated from a few sources or might be developing through a certain selective pressure. This is the first report on the molecular nature of the HIV-1 infection present in South Korea.
Full Text
https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=ovft&AN=00042560-199801010-00009&PDF=y
DOI
10.1097/00042560-199801010-00009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177010
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