국산 제2세대 혈소판보존용 혈액백의 평가

Abstract

Background : Polyvinyl(PVC) plastic container plasticized with di-(2-ethylhexyl) phthalate(DEHP) has been used for the storage of platelet concentrates for five days in Korea. Authors evaluated a second generation platelet storage container plasticized with tri(2-ethylhexyl) phthalate(TOTM) which was recently produced by Green Cross Medical Corp.(Korea). Methods : 30 units of platelet concentrates were stored in TOTM-PVC container at 22' C in a flatbed agitator Samples were taken at day 1,3,5, and 7 from the containers and tested for platelet count, MPV, PDW, pH, HCO3-,LDH, lactate, hypotonic shock response and β-thromboglobulin(β-TG). Electron microscopic examination was also performed. Results : The number and functions of platelets were well preserved during storage. pH was maintained above 6.8 and any evidence for platelet activation was minimal. Conclusion : The TOTM-PVC second generation platelet storage container recently produced by the Green Cross Medical Corp.(Korea) was able to preserve platelets for at least five days without significant storage lesions.