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Anti-DNA Autoantibodies from on MRL/Ipr Mouse

Authors
 Jeong Soo Park  ;  Young Tai Kim  ;  Chan Hee Lee  ;  Jung Koo Youn  ;  Young‐Ju Jang 
Citation
 Korean Journal of Biological Sciences, Vol.2(3) : 371-375, 1998 
Journal Title
 Korean Journal of Biological Sciences 
ISSN
 1226-5071 
Issue Date
1998
Abstract
Twenty-one monoclonal anti-DNA autoantilndies were produced by fusing spleen cells from an autoimmune MRL/lpr mouse with SP2/0 myeloma cells. Hybridomas generated by the fusions were chosen for cloning on the basis of DNA binding by supernatant antibody. Each monoclonal antibody was purified to homogeneity and analyzed for the heavy and light chain isotypes and the binding specificity for single-stranded DNA, double-stranded DNA, and RNA. Sequence specificities and isoelectric points of the antibodies were also examined. All of the antibodies were lgG and tended to bind to both single-stranded and double-stranded DNA with a preference for the double-stranded form. Some of them also bound to RNA. Isoelectric points of the antibodies were shown to be high. The antibodies described in this report have characteristics of pathogenic anti-DNA antibodies.
Full Text
https://www.tandfonline.com/doi/abs/10.1080/12265071.1998.9647433
DOI
10.1080/12265071.1998.9647433
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Soo Kon(이수곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176898
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