뇌실내 Thyrotropin-releasing Hormone이 위배출 기능에 미치는 영향

Abstract

Background/Aims: Gastric emptying is dependent on nutritive and physical charaeteristics of the ingested material, and external influences including extrnsic nerve supply, specific peptide hormone and neurotransmitters, Thyrotropin-releasing hormone (TRH) is one of the peptide hormones in the brain and is distributed in the brain part that controls gut motility. Recent studies have suggested the possibility that TRH is involved in central nervous regulation of gastric function. In the present study, we investigated the effects of intracerebroventricular (icv) administration of TRH on the gastric emptying in rats using acetaminophen absorption technique. Methods: Polyethylene tube was inserted into rat lateral ventricle which is restrained by stereotaxic apparatus. TRH was injected into lateral ventricle via tube 5 minutes before acetaminophen administration. Blood samples were collected 15, 30, 45, 60, 90, and 120 minutes after acetaminophen administration. Results: The icv injection of TRH enhanced gastric emptying, whereas intravenous injection exerted no effect. TRH-enhanced gastric emptying was blocked by atropine. Desipramine, which blocks the reuptake of norepinephrine into nerve terminal, exerted no effect on TRH-enhanced gastric emptying. Inhibition of gastric acid secretion by cimetidine exerted no effect on TRH-enhanced gastric emptying. Conclusions: TRH enhances gastric emptying by central nervous action which is mediated, in part, by cholinergic path-way.