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지속성 외래 복막투석 환자에서 사망률의 예측인자로서 혈청 C - Reactive Pritein 의 의의

Other Titles
 Serum C-Reactive Protein : A Predictor of Mortality in Continuous Ambulatory Peritoneal Dialysis(CAPD) Patients 
 노현진  ;  신석균  ;  이인희  ;  강신욱  ;  최규헌  ;  이호영  ;  한대석 
 Korean Journal of Nephrology (대한신장학회지), Vol.17(2) : 282-290, 1998 
Journal Title
Korean Journal of Nephrology(대한신장학회지)
Issue Date
An increased serum C-reactive protein(sCRP) has been demonstrated to be independent marker of mortality in hemodialysis patients, but predictive role of sCRP in CAPD patients is not clear. To evaluate the predictive value of the single baseline sCRP as a marker of mortality, we performed a corss-sectional study involving 105 CAPD patients and followed these patients for 2 years ratio was 0.9:1; mean CAPD duration was 43.5 months; 11.4% of patients had diabetes and 9.5% of patients had cardiovascular disease. Patients were divided into two groups based on sCRP level: normal sCRP group(n=92, sCRP≤0.8mg/dl) and increased sCRP group(n=13, sCRP>0.8mg/dl). The mean sCRP levels were 0.15±0.17 mg/dl and 4.25± 5.04mg/dl, respectively(P<0.05). In increased sCRP group, there were more diabetic patients(30.7 vs. 8.6%, P<0.05), and serum albumin level was significantly lower compared to normal sCRP group(3.5±0.6 vs. 3.9±0.5g/dl, P<0.05). Other biochemical, urea kinetic and anthropometric data showed no difference between the two groups . Two-year patient survival rate was significantly lower in increased sCRP group than normal sCRP group(66.7 vs. 94.1%, P=0.001) although there was no significant difference in technique failure, peritonitis rate and hospitalized days between the two groups. By Cox Proportional hazards analysis, independent predictors of mortality were cardiovascular disease (relative risk, RR=8.96, P<0.005), increased sCRP level(RR=1.19, P<0.05) and high hematocrit(RR=1.18, P<0.05). Serum CRP was negatively correlated with serum albumin(r=-0.20, P<0.05) and positively nor related with the presence of diabetes mellitus(r=0.31, P=0.001) by stepwise multiple regression analysis. In conclusion, sCRP at enrollment appears to be an independent predictor of 2-year patient survival in CAPD patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
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