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류마티스 관절염의 초치료와 불응성 류마티스 관절염의 치료에 있어 Bucillamine의 효과

Other Titles
 The Effect of Bucillamine in the Initial Treatment of Rheumatoid Arthritis and Treatment of Patients with Refractory Rheumatoid Arthritis 
 송창호  ;  이지수  ;  이찬희  ;  이충원  ;  서창희  ;  송정식  ;  이수곤 
 Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.5(1) : 83-88, 1998 
Journal Title
Journal of the Korean Rheumatism Association(대한류마티스학회지)
Issue Date
Objective : To assess the clinical effect of bucillamine in rheumatoid arthritis(RA), we performed an open clinical trial for 3 months.

Methods : 10 out of 12 patients completed bucillamine trial(200mg/day) for their initial treatment against arthritis, and 9 out of 11 patients with refractory RA completed the bucillamine trial. Disease activity was assessed by the duration of morning stiffness(MS), visual analogue pain scale(VAPS), functional capacity(FC), tender joint counts(TJC), swollen joint counts(SJC), ESR, and CRP every month. Adverse effects were monitored monthly.

Results : At the end of trial, all parameters were decreased in the initial treatment group except of CRP. No parameters were decreased in the refractory group. Gastrointestinal disturbance was the most commmon adverse effect. Skin rash, stomatitis, proteiuria and elevated hepatic enzyme were minor adverse effects.

Conclusion : Bucillamine was effective in the initial treatment of rheumatoid arthritis, but not effective in the patients with refractory rheumatoid arthritis. Bucillamine is relatively safe in the treatment of rheumatoid arthritis in both groups.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Soo Kon(이수곤)
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