주의력결핍 과잉운동장애 남아에서 중추신경자극제가 주의력과제 수행 중의 대뇌 기능적 국소화에 미치는 효과

Abstract

This study aims at investigating the effects of psychotimulant on functional cerebral localization during the attentional tasks in ADHD. Inclusional subjects were 13 boy between 6-12 years old who met the DSM-IV criteria for ADHD. In each patient, there was a drug-free period(without methyphenidate) and a drug-loaded period(with oral methylphenidate administration), and within each period there was a resting state and a stimulated state with TOVA. Comparisons were made by measuring the amplitudes of four bands(α,β,δ,θ) of quantitative EEG to see if there were any differences between the drug-free period(resting and stimulated) and the drug-loaded period(resting and stimulated). In the resting state, there was no difference between the drug-free and drug-loaded periods. In the stimulated state with TOVA, the presence of methylphenidate induced significant changes in the theta to beta ratio(θ/β) in the right frontal, right parieto-occipital, and left temporal-parietal areas in contrast to the drug-free period. These data suggest that methylphenidate shows electrophysiological influences on cerebral topographical activities during the attentional tasks in ADHD.