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한국인의 기능성 소화불량증 환자에서의 증상관찰, 아형분류 및 이에 대한 시사프리드의 효과

Other Titles
 Functional Dyspepsia and Subgroups in Korea and Short Term Outcome of Therapeutic Trial of Cisapride ; Multicenter Study 
 최명규  ;  최규완  ;  김나영  ;  임선희  ;  이계희  ;  김성국  ;  최용환  ;  송치욱  ;  김혜랑  ;  임창영  ;  배정동  ;  강필중  ;  안병민  ;  박수헌  ;  허충  ;  양창헌  ;  장재권  ;  이동호  ;  이국래  ;  설상영  ;  이연재  ;  한석원  ;  임규성  ;  이풍렬  ;  신원창  ;  이광재  ;  정문관  ;  나용호  ;  김준명  ;  김도영  ;  이선영  ;  김범수  ;  이돈행  ;  신용운  ;  권계숙  ;  유종선  ;  박현철  ;  정훈용  ;  민영일  ;  양석균  ;  정현용  ;  윤세진  ;  여향순  ;  문정섭  ;  박효진  ;  김학양  ;  이상우  ;  이용찬  ;  이문호  ;  최성호  ;  정미혜  ;  심찬섭  ;  이준성  ;  이상인  ;  강영우  ;  이종철 
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지), Vol.4(0) : 1-12, 1998 
Journal Title
 Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지) 
Issue Date
Background/Aims : The aims of this study were to determine subgoups of functional dyspesia and to evaluate the short-term effect of cisapride in patients with functional dyspepsia in Korea. Methods . 1025 patients, with a mean age of 42.6 years, with symptoms of functional dyspepsia, were recruited consecutively and upper gastrointestinal symptoms were investigated by interview in 41 hospitals in Korea. In an open, multicenter trial, 1025 patients received Smg of cisapride three times a day (TID) for at least .2 weeks for the treatment of symptoms of functional dyspepsia. When necessary, the dose of cisapride was increased to 10mg TID and the duration of therapy was extended to 4 weeks. Results . The most frequently reported symptoms of functional dyspepsia were epigastric discomfort or fullness (85%), bloating (70%), belching (53%), early satiety (52%) and epigastric pain (46%) retrospectively. Subgroups of functional dyspepsia were as follows; dysmotility-like 73.5%, ulcer-like 39.7%, reflux-like 13.0%, and unspecified dyspepsia 14.0%. However, 33.2% of subjects with functional dyspepsia could be classified into more than one subgroup. Upper gastrointestinal symptoms were decreased to average 50.3% (range; 42.2 to 59.2%) after 2 weeks of cisapride treatment and to 25% (19.2 to 29.9%) after 4 weeks. cisapride therapy resulted in good or excellent improvement in 59.0% of the patients after two weeks, in 75% of patients after 4 weeks. Adverse events were occurred in 52 patients (5.8% of all patients), most commonly, loose stools or diarrhea (3.5%), abdominal pain (1.1%), and dizziness (0.3%). The majority of adverse events was mild and transient in nature and led to premature discontinuation of treatment in 4 patients. Conclusions . Although the majorities of patients with functional dyspepsia have dysmotility like symptoms in Korea, there is such overlap among the dyspepsia subgroups. Most patients responded well to a short therapeutic trial with cisapride without significant side effects.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
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