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Effect of topical Na-hyaluronan on hemidesmosome formation in n-heptanol-induced corneal injury.

Authors
 Chung J.H.  ;  Kim W.K.  ;  Lee J.S.  ;  Pae Y.S.  ;  Kim H.J. 
Citation
 OPHTHALMIC RESEARCH, Vol.30(2) : 96-100, 1998 
Journal Title
 OPHTHALMIC RESEARCH 
ISSN
 0030-3747 
Issue Date
1998
MeSH
Administration, Topical ; Animals ; Burns, Chemical/metabolism* ; Cell Count ; Desmosomes/drug effects ; Desmosomes/metabolism* ; Epithelium, Corneal/metabolism* ; Eye Burns/chemically induced* ; Heptanol ; Hyaluronic Acid/administration & dosage ; Hyaluronic Acid/pharmacology* ; Morphogenesis ; Ophthalmic Solutions ; Rabbits ; Wound Healing/drug effects
Abstract
The present study investigated the effect of Na-hyaluronan (Na-HA) on the hemidesmosome morphogenesis in n-heptanol-induced corneal wounds. Central epithelial wounds were induced in the rabbit cornea by applying a 5.5-mm round filter paper, which was soaked in n-heptanol, for 60 s. 1% Na-HA in phosphate-buffered saline (PBS) or PBS alone were topically administered to the wounded cornea 4 times daily for up to 7 days. Epithelial healing rates during the first 2 days were not altered by Na-HA. The number of hemidesmosomes in the basement membrane of the central cornea was significantly increased in both 3- and 7-day groups after treatment with 1% Na-HA. The results suggest that topically applied 1% Na-HA may enhance the formation of hemidesmosomes during the early healing phase in n-heptanol-induced corneal wounds.
Full Text
http://www.karger.com/Article/FullText/55460
DOI
10.1159/000055460
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jin-Sung(이진성) ORCID logo https://orcid.org/0000-0002-1262-8597
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176582
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