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Membranoproliferative glomerulonephritis associated with HCV infection in native kidneys and renal allograft

Authors
 Hyeon Joo Jeong  ;  Kyu Hun Choi  ;  Chae Yoon Chon  ;  Soon Il Kim  ;  Kiil Park 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.13(6) : 670-675, 1998 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
1998
MeSH
Adult ; Female ; Glomerulonephritis, Membranoproliferative/pathology* ; Glomerulonephritis, Membranoproliferative/virology ; Hepacivirus/genetics ; Hepacivirus/isolation & purification ; Hepatitis C/blood ; Hepatitis C/pathology* ; Hepatitis C Antibodies/blood ; Humans ; Kidney Transplantation/pathology* ; Male ; Middle Aged ; RNA, Viral/blood
Abstract
Hepatitis C viral infection occurs relatively low in Korea compared to hepatitis B. However, it progresses into chronic hepatitis and cirrhosis more frequently than HBV. It may be associated with cryoglobulinemia and glomerulonephritis, both in native and transplanted kidneys. We report three cases of membrano-proliferative glomerulonephritis type I in anti-HCV positive, but cryoglobulin-negative patients, presenting massive proteinuria, two in native kidneys and one in an allograft. HCV-RNA was positive in sera of two patients. Two were cirrhotic and ALT was mildly elevated in two. In addition to the characteristic membranoproliferative feature, two native kidneys overlapped with features of diabetic nephropathy. Immunofluorescence demonstrated mainly IgM and C3 deposits along the peripheral capillary walls. Subendothelial electron dense deposits were present in the glomeruli of all three cases with subepithelial and intramembranous deposits in two. HCV-RNA was associated not only with a greater amount of immune deposits but also with subepithelial and intramembranous deposits, indicating the role of active infection.
Files in This Item:
T199801747.pdf Download
DOI
10.3346/jkms.1998.13.6.670
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176580
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