임신 중기 산모혈청 삼중 표지자를 이용한 다운증후군 태아의 선별검사 결과 위양성 산모의 임신 예후

Abstract

Objective: Our purpose was to study the pregnancy outcome in women whose triple marker screening [maternal serum AFP, unconjugated estriol, hCG, and maternal age] indicating an increased risk for Down syndrome [more than 1 : 270] was not confirmed by amniocentesis [false-positive result]. Methods: Between January 1995 and August 1997, 1,070 pregnant women undergoing second trimester triple marker screening for Down syndrome who gave birth at our institution were evaluated. The pregnancy outcomes of 56 women with false-positive screens for Down syndrome were compared with 1,014 screen negative controls. The pregnancy outcomes were obtained from hospital delivery records. Pregnancies with fetal chromosomal and structural anomalies were excluded from the study Results: An adverse pregnancy outcome occurred in 6 of 56 women [10.7%] with false-positive screens for Down syndrome, compared with 80 of 1,014[7.9%] in the screen negative controls [p＝0.291]. The study group was not significantly different from the control group in the incidence of preterm delivery [5.4% vs. 3.5%], preeclampsia [0% vs. 1.8%], abruptio placentae [0% vs. 0.2%], intrauterine growth retardation [5.4% vs. 2.0%], and fetal death [0% vs. 0.5%]. Among six women with adverse pregnancy outcome in the study group, low uE3 level[≤ 0.75 MoM] and high hCG level [≥ 2.0 MoM] were more frequently associated with adverse pregnancy outcome than low AFP level[≤ 0.4 MoM]. Conclusion: Women with false-positive screens for Down syndrome do not appear to be associated with adverse pregnancy outcomes.