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근골격계 종양에서 Telomerase 활성도 연구

Other Titles
 Telomerase Activity in Musculoskeletal Tumors 
Authors
 한수봉  ;  신규호  ;  이진우  ;  박규현  ;  정현철 
Citation
 Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지), Vol.1(1) : 40-47, 1998 
Journal Title
 Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지) 
ISSN
 1226-8933 
Issue Date
1998
Keywords
Musculoskeletal tumors ; Telomerase activity ; TRAP assay
Abstract
Telomerase activity has been detected in many human immortal cell lines and tumor tissues. We studied telomerase activity in a series of human musculoskeletal tumors. Twenty-seven tumors from 27 patients were studied using a sensitive PCR (polymerase chain reaction)-based technique, the TRAP (telomeric repeat amplication protocol) assy. Telomerase activity was present in seven tumors(25.9%). Telomerase activity was present in six of 18 malignant tumors(33.3%), while telomerase was active in one of 9 benign tumors(11.1%). Telomerase was active in 40% for osteosarcomas, 25% for soft tissue sarcomas, 16.7% for giant cell tumors of bone, and none for benign tumors. These results are a remarkablely low positive rate of telomerase activity in comparing with other types of carcinoma. In conclusion, it suggests that the Musculoskeletal tumors, arisen from mesenchymal cells, follow different pathways of neoplastic progression or it is due to the specific characteristics of sarcomas-abundant extracellular matrix and lack of tumor cells-differed from those of carcinomas.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Kyoo Ho(신규호)
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176516
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