83 242

Cited 0 times in

Protective mechanism of nitric oxide and mucus against ischemia/reperfusion-induced gastric mucosal injury

DC Field Value Language
dc.contributor.author김경환-
dc.date.accessioned2020-07-02T16:59:59Z-
dc.date.available2020-07-02T16:59:59Z-
dc.date.issued1998-
dc.identifier.issn1226-4512-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176515-
dc.description.abstractThis study investigated the role of nitric oxide on the oxidative damage in gastric mucosa of rats which received ischfmia/reperfusion and its relation to mucus. Nitric oxide synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester, and sodium nitroprusside, a nitric oxide donor, were injected intraperitoneally to the rats 30 min prior to ischemia/reperfusion which was induced by clamping the celiac artery and the superior mesenteric artery for 30 min and reperfusion for 1 h. Lipid peroxide production, the contents of glutathione and mucus, and glutathione peroxidase activities of gastric mucosa were determined. Histological observation of gastric mucosa was performed by using hematoxylin-eosin staining and scanning electron microscopy. The result showed that ischemia/reperfusion increased lipid peroxide production and decreased the contents of glutathione and mucus as well as glutathione peroxidase activities of gastric mucosa. Ischemia/reperfusion induced gastric erosion and gross epithelial disruption of gastric mucosa. Pretreatment of L-arginine, a substrate for nitric oxide synthase, and sodium nitroprusside prevented ischemia/reperfusion-induced alterations of gastric mucosa. However, N G -nitro- L-arginine methyl ester, a nitric oxide synthase inhibitor, deteriorated oxidative damage induced by ischemia/reperfusion. In conclusion, nitric oxide has an antioxidant defensive role on gastric mucosa by maintaining mucus, glutathione, and glutathione peroxidase of gastric mucosa.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한약리학회-
dc.relation.isPartOfKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleProtective mechanism of nitric oxide and mucus against ischemia/reperfusion-induced gastric mucosal injury-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학교실)-
dc.contributor.googleauthorHyeyoung Kim-
dc.contributor.googleauthorKwangsoo Nam-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.localIdA00311-
dc.relation.journalcodeJ02104-
dc.identifier.eissn2093-3827-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.affiliatedAuthor김경환-
dc.citation.volume2-
dc.citation.number4-
dc.citation.startPage511-
dc.citation.endPage519-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.2(4) : 511-519, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.