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Clonal expansion of T-cells in measles

DC Field Value Language
dc.contributor.author김동수-
dc.contributor.author최인홍-
dc.date.accessioned2020-07-02T16:59:43Z-
dc.date.available2020-07-02T16:59:43Z-
dc.date.issued1998-
dc.identifier.issn0165-2478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176512-
dc.description.abstractSome autoimmune complications such as postinfectious encephalomyelitis are associated with immunologic abnormalities induced by measles virus infection. To address the superantigenic stimulation in measles which might be related with autoimmune complications, T-cells bearing the TCRBV5S2 or TCRBV8 chains and the expression of activation markers were analyzed by monoclonal antibodies. To estimate clonal expansions, the CDR3 length profile in T-cells bearing the TCRBV5S2 or TCRBV8 chains was analyzed by two-stage PCR. Results showed that the expression of DR molecules in CD3+ cells was increased significantly in measles patients (19.6 +/- 20.7%) compared to healthy children (2.9 +/- 1.4%). The mean percentage (7.1 +/- 4.4%) of T-cells bearing the TCRBV8 chain was increased in measles patients compared to healthy children (5.6 +/- 3.1%). The percentage of T-cells bearing the TCRBV5S2 chain in measles patients (3.0 +/- 1.2%) was similar to that in healthy children (2.7 +/- 0.6%). By analysis of the CDR3 length we found that there was no evidence of clonal expansions in T-cells bearing the TCRBV8 chain and that there were clonal expansions in T-cells bearing the TCRBV5S2 chain. These data suggest a conventional antigenic stimulation with T-cells bearing the TCRBV5S2 chain and a superantigenic stimulation with T-cells bearing the TCRBV8 chain may occur in the acute stage of measles infection.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier/North-Holland Biomedical Press-
dc.relation.isPartOfIMMUNOLOGY LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntibodies, Monoclonal/immunology-
dc.subject.MESHAutoimmune Diseases/complications-
dc.subject.MESHCD3 Complex/analysis-
dc.subject.MESHCD3 Complex/genetics-
dc.subject.MESHCD4-CD8 Ratio-
dc.subject.MESHChild, Preschool-
dc.subject.MESHClone Cells-
dc.subject.MESHFemale-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHGenes, T-Cell Receptor beta/genetics-
dc.subject.MESHHLA-DR Antigens/analysis-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMeasles/complications-
dc.subject.MESHMeasles/immunology*-
dc.subject.MESHPolymerase Chain Reaction/methods-
dc.subject.MESHReceptors, Antigen, T-Cell, alpha-beta/analysis-
dc.subject.MESHReceptors, Interleukin/analysis-
dc.subject.MESHSuperantigens/immunology-
dc.subject.MESHT-Lymphocytes/immunology*-
dc.titleClonal expansion of T-cells in measles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorYong-Joon Chwae-
dc.contributor.googleauthorIn-Hong Choi-
dc.contributor.googleauthorDong-Soo Kim-
dc.contributor.googleauthorEui-Cheol Shin-
dc.contributor.googleauthorDae-Ho Kwon-
dc.contributor.googleauthorSe-Jong Kim-
dc.contributor.googleauthorJoo-Deuk Kim-
dc.identifier.doi10.1016/s0165-2478(98)00068-6-
dc.contributor.localIdA00405-
dc.contributor.localIdA04167-
dc.relation.journalcodeJ01038-
dc.identifier.eissn1879-0542-
dc.identifier.pmid9840683-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0165247898000686-
dc.contributor.alternativeNameKim, Dong Soo-
dc.contributor.affiliatedAuthor김동수-
dc.contributor.affiliatedAuthor최인홍-
dc.citation.volume63-
dc.citation.number3-
dc.citation.startPage147-
dc.citation.endPage152-
dc.identifier.bibliographicCitationIMMUNOLOGY LETTERS, Vol.63(3) : 147-152, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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