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유방암에서 현미 부수체 불안정성(Microsatellite Instability)의 발현이 예후에 미치는 영향

Other Titles
 Microsatellite Instability Correlate with a Prognosis in Breast Cancer 
 이화영  ;  전성실  ;  공수정  ;  박준오  ;  안중배  ;  심광용  ;  라선영  ;  유내춘  ;  양우익  ;  김주항  ;  노재경  ;  이경식  ;  김병수  ;  정현철 
 Journal of the Korean Cancer Association (대한암학회지), Vol.30(5) : 914-920, 1998 
Journal Title
 Journal of the Korean Cancer Association (대한암학회지) 
Issue Date
Breast cancer ; Microsatellite instability ; Replication error ; TGF-beta ; TGF-beta RII
PURPOSE: Microsatellite instability in patients with defects in the mismatch repair system resulting in RER has a high risk of accumulating mutations in oncogene and tumor suppressor gene. In this study, we evaluated the incidence of microsatellite instability in breast cancer by comparing PCR-amplified sequences from frozen samples of normal and tumor tissue fram affected patients. We also investigated whether RER was associated with TGF-beta RII mutation. MATERIALS AND METHODS: Fifty surgically resected breast cancer specimens from Jan. 1996 to June, 1997 were used for study. Microsatellite instability(referred to as replication error, RER) at three loci with BAT 26, BAT 40, TA10 was analyzed by polymerase chain reaction and the results were compared with clinicopathologic characteristics. RESULTS: Of the 50 breast cancer patients, 14(28%) were RER(+) at one or more microsatellite loci, and 4(8%) showed TGF-beta RII mutation. Microsatellite instability was significantly correlated with lymph node involvement(especially in case of 4 or more lymph nodes involvement). But we could not find any correlation between RER and other prognostic factors including tumor size, tumor grade, hormone receptor status and pathology. One of fourteen tumors with RER(+) showed TGF-beta RII mutstion. There was no signiticant correlation between RER(+) and TGF-beta type II receptor gene mutation. CONCLUSION: The findings suggest that microsatellite instability would be useful prognostic factor in unilateral breast cancer patients, and the role of targeting to gene mutation will be explored in future studies.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
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