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담낭암 발생에서 담췌관합류이상의 역할 규명과 암화과정에 관한 연구

Other Titles
 Carcinogenesis of Gallbladder Cancer in Anomalous Pancreaticobiliary Ductal Union 
 한기준  ;  강진경  ;  정재복  ;  송시영  ;  이세준  ;  김호근 
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.32(4) : 525-535, 1998 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Background/Aims : To clarify the carcinogenesis of gallbladder cancer (GBC) in patients/ with anomalous pancreaticobiliary ductal union (APBDU), we investigated the expression of mutated p53 protein and c-erbB2, the cell proliferation indices of Ki-67 and the histopathologic changes in gallbladder carcinoma and noncancerous mucosa which are associated with APBDU. Methods : In the clinical review, we analysed 62 patients (27 patients of GBC with APBDU and 35 patients of GBC without APBDU) who were diagnosed in Sevrance Hospital from January, 1992 to December, 1994. Immunohistochemical staining and histologic examination were performed on the specimens obtained from surgically resected gallbladders from the patients. For comparative study, the specimens were grouped as follows: 5 cases of carcinoma with APBDU, 4 cases of noncancerous mucosa with APBDU associated with GHC, 11 cases of noncancerous mucosa with APBDU not associated with GBC, 19 cases of carcinoma without APBDU and 7 cases of chronic inflammatory mucosa of gallbladder stones as controls. Results: GBC developed in 33.3% of patients with APBDU (especially, 66.1% of PC type) and showed no gallbladder stones. The frequency of papillary carcinoma was higher and depth of invasion was less in GBC with APBDU than in GBC without APBDU. Among 15 cases of noncancerous mucosa with APBDU, isolated dysplasia and adenomyomatous hyperplasia were noted in 10 cases and 4 cases, respectively. In one case of APBDU with GBC, the expression of p53 protein was noted in the focal area of low grade dysplasia. Cell proliferation indices of Ki-67 were stepwise increased with the progression of histologic findings from inflammation, papillary hyperplasia, metaplasia and adenomyomatous hyperplasia to dysplasia. Particularly, remarkable increase was observed in adenomyomatous hyperplasia and dysplasia. Conclusions : The high incidence of isolated dysplasia and adenomyoma accompanying with increased cell proliferative indices seems to be closely related to the carcinogenesis of GBC in patients with APBDU. Additionally, the mutation of p53 may contribute to early event of carcinogenesis in some patients with APBDU.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Jae Bock(정재복)
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