11 19

Cited 0 times in

Computed numerical analysis of the biomechanical effects on coronary atherogenesis using human hemodynamic and dimensional variables

Authors
 Byoung Kwon Lee  ;  Hyuck Moon Kwon  ;  Dongsoo Kim  ;  Young Won Yoon  ;  Jeong Kee Seo  ;  In Jai Kim  ;  Hyung Woon Roh  ;  Sang Ho Suh  ;  Sang Sin Yoo  ;  Hyun Seung Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.39(2) : 166-174, 1998 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
1998
MeSH
Biomechanical Phenomena ; Blood Flow Velocity/physiology ; Blood Pressure/physiology ; Coronary Artery Disease/etiology* ; Coronary Artery Disease/physiopathology* ; Coronary Vessels/physiopathology* ; Hemodynamics/physiology* ; Homeostasis/physiology ; Humans ; Models, Cardiovascular* ; Pulsatile Flow ; Stress, Mechanical
Abstract
The objectives of this investigation were to evaluate biomechanical factors in the atherosclerotic process using human in vivo hemodynamic parameters and computed numerical simulation qualitatively and quantitatively. The three-dimensional spatial patterns of steady and pulsatile flows in the left coronary artery were simulated, using a finite volume method. Coronary angiogram and Doppler ultrasound measurement of the proximal left coronary flow velocity were performed in humans. Inlet wave velocity distribution obtained from in vivo data of the intravascular Doppler study allowed for input of in vitro numerical simulation. Hemodynamic variables, such as flow velocity, pressure and shear stress of the left anterior descending coronary bifurcation site were calculated. We found that there were spatial fluctuation of flow-velocity and recirculation areas at the curved outer wall of the left anterior descending coronary artery, which were due to the differences of flow-velocity and shear stress, especially during the declaration phase of pulsatile flow. This study suggests that rheologic properties may be a part of the atherogenic process in the coronary bifurcated and curved areas.
Files in This Item:
T199801258.pdf Download
DOI
10.3349/ymj.1998.39.2.166
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176402
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links