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Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice

DC FieldValueLanguage
dc.contributor.author박광균-
dc.date.accessioned2020-07-02T16:48:43Z-
dc.date.available2020-07-02T16:48:43Z-
dc.date.issued1998-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176375-
dc.description.abstractA wide array of phytochemicals have been shown to possess potential cancer chemopreventive properties. Ginger contains pungent phenolic substances with pronounced antioxidative and antiinflammatory activities. In the present study, we have determined the antitumor promotional activity of [6]-gingerol, a major pungent principle of ginger, using a two-stage mouse skin carcinogenesis model. Topical application of [6]-gingerol onto shaven backs of female ICR mice prior to each topical dose of 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis. The compound also suppressed TPA-induced epidermal ornithine decarboxylase activity and inflammation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Ireland-
dc.relation.isPartOfCANCER LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESH9,10-Dimethyl-1,2-benzanthracene-
dc.subject.MESHAnimals-
dc.subject.MESHCapillary Permeability/drug effects-
dc.subject.MESHCatechols-
dc.subject.MESHCurcumin/pharmacology-
dc.subject.MESHEpidermis/drug effects-
dc.subject.MESHEpidermis/enzymology*-
dc.subject.MESHFatty Alcohols/pharmacology*-
dc.subject.MESHFemale-
dc.subject.MESHInflammation/chemically induced-
dc.subject.MESHInflammation/prevention & control*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHOrnithine Decarboxylase/metabolism-
dc.subject.MESHOrnithine Decarboxylase Inhibitors*-
dc.subject.MESHPlants, Medicinal-
dc.subject.MESHSkin Neoplasms/chemically induced-
dc.subject.MESHSkin Neoplasms/prevention & control*-
dc.subject.MESHTetradecanoylphorbol Acetate-
dc.titleInhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorKwang-Kyun Park-
dc.contributor.googleauthorKyung-Soo Chun-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorSang Sup Lee-
dc.contributor.googleauthorYoung-Joon Surh-
dc.identifier.doi10.1016/s0304-3835(98)00081-0-
dc.contributor.localIdA01429-
dc.relation.journalcodeJ00448-
dc.identifier.eissn1872-7980-
dc.identifier.pmid9719454-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0304383598000810-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.affiliatedAuthor박광균-
dc.citation.volume129-
dc.citation.number2-
dc.citation.startPage139-
dc.citation.endPage144-
dc.identifier.bibliographicCitationCANCER LETTERS, Vol.129(2) : 139-144, 1998-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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