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정상인의 전혈(Whole blood)에서 Triflusal(Disgren®)에 의한 혈소판 응집 억제 효과

Other Titles
 The Inhibitory Effect of Triflusal(Disgren®) on the Platelet Aggregation in Healthy Volunteers : Impedance Method with the Whole Blood 
 강석민  ;  정광회  ;  김태용  ;  안신기  ;  하종원  ;  임세중  ;  이문형  ;  백금련  ;  장양수 
 Korean Circulation Journal (순환기), Vol.28(5) : 707-714, 1998 
Journal Title
 Korean Circulation Journal (순환기) 
Issue Date
Background : Antiplatelet drugs play an important role in the prevention and treatment of coronary artery diseases. Triflusal, an antiplatelet drug structually related to acetylsalicylic acid, selectively inhibits the cyclooxygenase of platelet and thromboxane A, formation. However there is a controversy about the clinical dosage and the quantitative evaluation of the platelet antiaggregatory effect of triflusal. In this study we have evaluated the platelet antiaggregatory effect and cost-effective dosage of triflusal in the whole blood of healthy volunteers. Methods : Using the whole blood of 50 healthy people, we performed a baseline platelet aggregation function test induced by adenosine diphosphate (ADP) and collagen. The subjects were subdivided into 3 treated groups (300 mg, 600 mg, 900 mg). We compared the platelet aggregation effect between the baseline results and 2 weeks after triflusal administration. Results : Triflusal inhibited the platelet aggregation . induced by ADP and collagen in the 600 mg administration group most effectively. The platelet aggregation induced by collagen was inhibited dose-dependently. The definite inhibitory responders (% inhibition >_ 25) for platelet aggregation induced by collagen were more common than those induced by ADP (33% vs 27% in 300 mg, 71% vs 53% in 600 mg, 78% vs 39% in 900 mg). There were no serious clinical side-effects except gastrointestinal trouble. One volunteer in the 900 mg treated group discontinued the treatment due to epigastric pain. Conclusion : We conclude that triflusal has a dose-dependent inhibitory effect on platelet aggregation induced by collagen and that the most effective dosage for platelet antiaggregation effect is 600 mg per day.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Shin Ki(안신기) ORCID logo https://orcid.org/0000-0002-9822-7961
Lee, Moon-Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
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