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만성췌장염 환자에서 Bentiromide 검사와 내시경적 역행성 췌관조영술소견의 비교

Other Titles
 A Comparatibe Study between the Bentiromide Test and Endoscopic Retrograde Pancreatography in Patients with Chronic Pancreatitis 
 강진경  ;  박인서  ;  문영명  ;  정재복  ;  송시영  ;  박승우 
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.31(2) : 220-226, 1998 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Background/Aims: The bentiromide test has been used to evaluate pancreatic function in patients with chronic pancreatitis. The bentiromide test has some advantages over the traditional pancreozymin-secretin (P-S) test. It does not require duodenal intubation and the analytic method is relatively simple. Some researchers reported that the result of the bentiromide test correlated with that of the P-S test. The advent of endoscopic retrograde pancreatography (ERP) affords the opportunity to analyze the secretory abnormalities of patients with chronic pancreatitis with references to alteration in pancreatic ductal morphology. Precise correlation between the result of the P-S test and the pancreatic ductal morphology obtained by ERP in chronic pancreatitis have not hitherto been established. Furthermore, there is no published report in which a researcher compares tbe bentiromide test with the ERP. In order to document its clinical usefulness in chronic pancreatitis, we performed bentiromide tests in patients with chronic pancreatitis and compared its findings with that of the ERP. Methods: Bentiromide tests were performed in 7 control subjects and in 25 patients with chronic pancreatitis who had pancreatic ductal abnormalities on ERP. The cumulative 6 hour urinary recovery rate of para-aminobenzoic acid (PABA) in the urine was determined in each patient and control. The results were compared with the pancreatic ductal abnormalities which had been categorized by Cambridge classification. Results: The cumulative 6 hour recovery rate of PABA in the urine was significantly lower in patients with chronic pancreatitis (55.8+-24.2%, p<0.05) than in the control group (82.0+-10.0%), but among the 25 patients with chronic pancreatitis, 7 patients showed normal recovery rates of PABA. According to the Cambridge classification, the pancreatograms of 25 patients were categorized as mild changes in 4 patients, moderate changes in 5 patients, and severe changes in 16 patients. The 6 hour recovery rate.s of PABA were 56.9+-21.6% and abnormal in 3 (75%) in mild changes group, 78.4 +-10.5% and abnormal only in 1 (20%) in moderate changes group, and 47.2+-23.7% and abnormal in 14 (87.5%) in marked changes group. We could find no significant difference in 6 hour recovery rates of PABA among the groups, nor correlation between the pancreatic ductal changes and the pancreatic exocrine function. Conclusions: The bentiromide test can be used in the evaluation of pancreatic exocrine function in patients with chronic pancreatitis, but the test does not correlate with pancreatic ductal changes.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Chung, Jae Bock(정재복)
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