습관성 자연유산을 경험한 130 쌍의 부부에서 시행한 세포유전학적 검사 결과 분석

Abstract

Background :Chromosomal aberration of a couple can lead to recurrent miscarriage and it has been accounted for 2-10% of recurrent spontaneous abortions in the Caucasian population The purpose of this stuffy is to evaluate the frequency of chromosomal abnormalities in couples having fetal losses. We also attempted to define the relationship of those chromosome rearrangements with the presence or absence of stillborn fetus or malformed live child Method :A total of 130 couples with two or more spontaneous abortions were studied. Chromosome studios were performed on metaphases using standard peripheral lymphocyte culture technique Result :Ten (77%) chromosomal abnormalities were detected, 7 (5,4%) in women and 3 23%) in men. The chance of finding chromosomal abnormality in couples with stillborn fetus or malformed live child was higher than in couples with spontaneous abortions but no other adverse event, but the difference was not statistically significant. Conclusion :Cytogenetic analysis was indicated in couples with recurrent spontaneous abortions The chance of chromosomal abnormality in couples with stillborn fetus or malformed live child was higher.