Cited 23 times in
Effect of nitric oxide on hydrogen peroxide-induced damage in isolated rabbit gastric glands
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2020-07-02T16:42:26Z | - |
dc.date.available | 2020-07-02T16:42:26Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0031-7012 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176308 | - |
dc.description.abstract | The present study aims at investigating the effects of nitric oxide (NO) on hydrogen peroxide (H2O2)-induced damage in isolated rabbit gastric glands. NO synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) and an NO donor, sodium nitroprusside, were added to isolated rabbit gastric glands exposed to H2O2, generated by glucose oxidase acting on beta-D-glucose. As a result, glucose/glucose oxidase caused an increase in lipid peroxide production and decreases in reduced glutathione (GSH) content, GSH peroxidase activity, nitrite release, and mucus secretion in gastric glands. The alterations in lipid peroxide production, GSH content, and mucus secretion were prevented by pretreatment with L-arginine, a substrate for NO synthase and sodium nitroprusside, but not by L-NAME. In conclusion, NO protects gastric glands from H2O2 by inhibiting lipid peroxidation and maintaining cellular GSH content and mucus secretion. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Drug Interactions | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Gastric Mucosa/drug effects* | - |
dc.subject.MESH | Gastric Mucosa/enzymology | - |
dc.subject.MESH | Gastric Mucosa/metabolism | - |
dc.subject.MESH | Glutathione Peroxidase/metabolism | - |
dc.subject.MESH | Hydrogen Peroxide/toxicity* | - |
dc.subject.MESH | Lipid Peroxides/biosynthesis* | - |
dc.subject.MESH | NG-Nitroarginine Methyl Ester/pharmacology | - |
dc.subject.MESH | Nitric Oxide/pharmacology* | - |
dc.subject.MESH | Nitroprusside/pharmacology | - |
dc.subject.MESH | Peroxidases/pharmacology | - |
dc.subject.MESH | Rabbits | - |
dc.title | Effect of nitric oxide on hydrogen peroxide-induced damage in isolated rabbit gastric glands | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Hyeyoung Kim | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.identifier.doi | 10.1159/000028258 | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J02509 | - |
dc.identifier.eissn | 1423-0313 | - |
dc.identifier.pmid | 9792973 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/28258 | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.citation.volume | 57 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 323 | - |
dc.citation.endPage | 330 | - |
dc.identifier.bibliographicCitation | PHARMACOLOGY, Vol.57(6) : 323-330, 1998 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.