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고양이에서 Galactosamine에 의한 급성간부전이 Mivacurium의 근이완 작용에 미치는 영향

Other Titles
 Effects of Acute Hepatic Failure by Galactosamine on Mivacurium-induced Neuromuscular Blockade in the Cats 
 김순열  ;  김천경  ;  임현교  ;  윤경봉 
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.34(2) : 266-272, 1998 
Journal Title
 Journal of Korean Society of Anesthesiologist (대한마취과학회지) 
Issue Date
Background: Though the mivacurium is the short acting nondepolarizing neuromuscular blocking agent, the action duration of it is not prospected in condition of hepatic failure owing to its being metabolized by serum cholinesterase and other esterase produced in liver. The purpose of this study is to evaluate neuromuscular effect of the mivacurium in cats with acute hepatic failure. Methods: Six cats administrated only mivacurium are the control group, and six cats with acute hepatic failure by galactosamine hydrochloride are the experimental group. The force of the anterior tibialis muscle in response to supramaximal common peroneal nerve stimulations were recorded, the time intervals from mivacurium administration to attain 100% twitch depression (onset time), from mivacurium administration to recovery of 25% twitch tension(duration) and from 25% to 75% of twitch recovery (recovery index) were compared between the control group and the experimental group. Results: In experimental group, SGOT and SGPT prior to administration of galatosamine were 28.8±5.6(IU/L) and 43.0±7.9(IU/L), respectively, SGOT and SGPT in acute hepatic failure were 5004.0±8113.2(IU/L) and 3763.0±5416.4(IU/L), respectively, and there were significant differences between the control group and the experimental group. The action duration{47.6±18.0(min)} and the recovery time{7.7±3.7(min)} of mivacurium in the experimental group were more prolonged than the action duration{21.9±5.0(min)} and the recovery time{4.4±0.7(min)} of mivacurium in the control group. Conclusions: These results indicate that the hepatic failure can prolong the action duration and the recovery index of mivacurium, but the other factors affecting the action of mivacurium must be studied
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Kyoung Bong(윤경봉) ORCID logo https://orcid.org/0000-0002-4167-1375
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