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Homozygous deletions of the CDKN2 gene and loss of heterozygosity of 9p in primary hepatocellular carcinoma

Authors
 Zhe Piao  ;  Chanil Park  ;  Jin-Sung Lee  ;  Chang Hyun Yang  ;  Kang Yell Choi  ;  Hoguen Kim 
Citation
 CANCER LETTERS, Vol.122(1~2) : 201-207, 1998 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
1998
MeSH
Carcinoma, Hepatocellular/genetics* ; Carcinoma, Hepatocellular/pathology ; Chromosomes, Human, Pair 9* ; Cyclin-Dependent Kinase Inhibitor p16/genetics* ; Genes, Tumor Suppressor* ; Humans ; Liver Neoplasms/genetics* ; Liver Neoplasms/pathology ; Loss of Heterozygosity* ; Mutation
Abstract
To elucidate the alterations of CDKN2 in hepatocarcinogenesis, we performed a loss of heterozygosity (LOH) study using eight polymorphic markers surrounding the CDKN2 gene and analyzed the homozygous deletions and mutations of the CDKN2 gene in 41 primary hepatocellular carcinomas (HCCs). Frequent LOH (27.8-44%) was found in the eight loci on chromosome 9p, however, no intragenic mutations of CDKN2 were observed by PCR-SSCP analysis. Homozygous deletions were detected in 25 of 41 HCCs (61%) by a comparative multiplex PCR. No expression of the CDKN2 protein was noted in five out of nine available HCCs by Western blot analysis. These results suggest that inactivation of the CDKN2 gene in HCC is a frequent event in which homozygous deletions are the most common mechanism of CDKN2 inactivation.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304383597004035
DOI
10.1016/s0304-3835(97)00403-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176290
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