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A National Consensus Survey for Current Practice in Brain Tumor Management II: Diffuse Midline Glioma and Meningioma

 Sung Kwon Kim  ;  Hong In Yoon  ;  Wan Soo Yoon  ;  Jin Mo Cho  ;  Jangsup Moon  ;  Kyung Hwan Kim  ;  Se Hoon Kim  ;  Young Il Kim  ;  Young Zoon Kim  ;  Ho Sung Kim  ;  Yun Sik Dho  ;  Jae Sung Park  ;  Ji Eun Park  ;  Youngbeom Seo  ;  Kyoung Su Sung  ;  Jin Ho Song  ;  Chan Woo Wee  ;  Se Hoon Lee  ;  Do Hoon Lim  ;  Jung Ho Im  ;  Jong Hee Chang  ;  Myung Hoon Han  ;  Je Beom Hong  ;  Kihwan Hwang  ;  Chul Kee Park  ;  Youn Soo Lee  ;  Ho Shin Gwak  ;  KSNO Guideline Working Group 
 Brain Tumor Research and Treatment, Vol.8(1) : 11-19, 2020-04 
Journal Title
 Brain Tumor Research and Treatment 
Issue Date
Brain tumors ; Diffuse midline glioma ; Korean Society for Neuro-Oncology ; Meningioma, Guideline Working Group ; Practice patterns
Background: The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted a nationwide questionnaire survey for diverse queries faced in the treatment of brain tumors. As part II of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with diffuse midline glioma and meningioma. Methods: A web-based survey was sent to all members of the KSNO by email. The survey included 4 questions of diffuse midline glioma and 6 questions of meningioma (including 2 case scenarios). All questions were developed by consensus of the Guideline Working Group. Results: In the survey about diffuse midline glioma, 76% respondents performed histologic confirmation to identify H3K27M mutation on immunohistochemical staining or sequencing methods. For treatment of diffuse midline glioma, respondents preferred concurrent chemoradiotherapy with temozolomide (TMZ) and adjuvant TMZ (63.8%) than radiotherapy alone (34.0%). In the survey about meningioma, respondents prefer wait-and-see policy for the asymptomatic small meningioma without peritumoral edema. However, a greater number of respondents had chosen surgical resection as the first choice for all large size meningiomas without exception, and small size meningiomas with either peritumoral edema or eloquent location. There was no single opinion with major consensus on long-term follow-up plans for asymptomatic meningioma with observation policy. As many as 68.1% of respondents answered that they would not add any adjuvant therapies for World Health Organization grade II meningiomas if the tumor was totally resected including dura. Conclusion: The survey demonstrates the prevailing clinical practice patterns for patients with diffuse midline glioma and meningioma among members of the KSNO. This information provides a point of reference for establishing a practical guideline in the management of diffuse midline glioma and meningioma.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Yoon, Hong In(윤홍인) ORCID logo https://orcid.org/0000-0002-2106-6856
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
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