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Prognostic Significance of Transient Receptor Potential Vanilloid Type 1 (TRPV1) and Phosphatase and Tension Homolog (PTEN) in Epithelial Ovarian Cancer

Authors
 Gwan Hee Han  ;  Doo Byung Chay  ;  Sanghee Nam  ;  Hanbyoul Cho  ;  Joon-Yong Chung  ;  Jae-Hoon Kim 
Citation
 CANCER GENOMICS & PROTEOMICS, Vol.17(3) : 309-319, 2020-05 
Journal Title
 CANCER GENOMICS & PROTEOMICS 
ISSN
 1109-6535 
Issue Date
2020-05
Keywords
Epithelial ovarian cancer ; PTEN ; TRPV1 ; tumor marker
Abstract
Background: Transient receptor potential vanilloid type 1 (TRPV1) has been studied in human malignancies, but has not been studied in epithelial ovarian cancer (EOC). We, therefore, investigated the significance of TRPV1 and correlation with phosphatase and tension homolog (PTEN) in EOC. Materials and methods: Immunohistochemical analyses for TRPV1 and PTEN were performed using a tissue microarray. Moreover, the role of TRPV1 in cell growth was assessed in a EOC cell line. Results: High TRPV1 expression and the combination of high TRPV1 and low PTEN expression were an independent prognostic factor for overall survival and disease-free survival. In vitro results demonstrated that knockdown of TRPV1 was associated with decreased cell viability and colony formation. Conclusion: There is a strong association between TRPV1 and PTEN and the combination of TRPV1 and PTEN is a strong indicator of prognostic predictor in EOC.
Files in This Item:
T202001645.pdf Download
DOI
10.21873/cgp.20191
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Cho, Hanbyoul(조한별) ORCID logo https://orcid.org/0000-0002-6177-1648
Chay, Doo Byung(채두병) ORCID logo https://orcid.org/0000-0002-0648-4021
Han, Gwan Hee(한관희) ORCID logo https://orcid.org/0000-0001-5263-4855
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176211
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