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Prognostic Role of Serum High Mobility Group Box 1 Concentration in Cardiac Surgery

DC Field Value Language
dc.contributor.author곽영란-
dc.contributor.author김남오-
dc.contributor.author심재광-
dc.contributor.author이삭-
dc.contributor.author이정림-
dc.date.accessioned2020-06-17T00:48:07Z-
dc.date.available2020-06-17T00:48:07Z-
dc.date.issued2020-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176128-
dc.description.abstractOutcomes of cardiac surgery are influenced by systemic inflammation. High mobility group box 1 (HMGB1), a pivotal inflammatory mediator, plays a potential role as a prognostic biomarker in cardiovascular disease. The aim of this prospective, observational study was to investigate the relationship between serum HMGB1 concentrations and composite of morbidity endpoints in cardiac surgery. Arterial blood samples for HMGB1 measurement were collected from 250 patients after anaesthetic induction (baseline) and 1 h after weaning from cardiopulmonary bypass (post-CPB). The incidence of composite of morbidity endpoints (death, myocardial infarction, stroke, renal failure and prolonged ventilator care) was compared in relation to the tertile distribution of serum HMGB1 concentrations. The incidence of composite of morbidity endpoints was significantly different with respect to the tertile distribution of post-CPB HMGB1 concentrations (p = 0.005) only, and not to the baseline. Multivariable analysis revealed post-CPB HMGB1 concentration (OR, 1.072; p = 0.044), pre-operative creatinine and duration of CPB as independent risk factors of adverse outcome. Accounting for its prominent role in mediating sterile inflammation and its relation to detrimental outcome, HMGB1 measured 1 h after weaning from CPB would serve as a useful biomarker for accurate risk stratification in cardiac surgical patients and may guide tailored anti-inflammatory therapy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePrognostic Role of Serum High Mobility Group Box 1 Concentration in Cardiac Surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorNamo Kim-
dc.contributor.googleauthorSak Lee-
dc.contributor.googleauthorJeong-Rim Lee-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.contributor.googleauthorJi-Hae Jun-
dc.contributor.googleauthorJae-Kwang Shim-
dc.identifier.doi10.1038/s41598-020-63051-2-
dc.contributor.localIdA00172-
dc.contributor.localIdA00356-
dc.contributor.localIdA02205-
dc.contributor.localIdA02807-
dc.contributor.localIdA03098-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid32286371-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.affiliatedAuthor곽영란-
dc.contributor.affiliatedAuthor김남오-
dc.contributor.affiliatedAuthor심재광-
dc.contributor.affiliatedAuthor이삭-
dc.contributor.affiliatedAuthor이정림-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage6293-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.10(1) : 6293, 2020-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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