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Clinical Relationship Between Anemia and Atrial Fibrillation Recurrence After Catheter Ablation Without Genetic Background

DC FieldValueLanguage
dc.contributor.author김인수-
dc.contributor.author김종윤-
dc.contributor.author김태훈-
dc.contributor.author박희남-
dc.contributor.author엄재선-
dc.contributor.author유희태-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.contributor.author김민-
dc.date.accessioned2020-06-17T00:43:21Z-
dc.date.available2020-06-17T00:43:21Z-
dc.date.issued2020-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176098-
dc.description.abstractBackground: Anemia is a known adverse prognostic factor among patients with cardiovascular diseases. We investigated whether the hemoglobin level was associated with the rhythm outcome after atrial fibrillation (AF) catheter ablation (AFCA). Methods: We included 2627 patients who underwent AFCA and a guidelines-based rhythm follow-up (age 58 ± 10.9 years, 73% men, 30.6% with persistent AF), and evaluated the association of pre-AFCA anemia (haemoglobin <13 g/dL in men and <12 g/dL in women) and rhythm outcomes. We studied the mechanistic relationship between anemia and AF recurrence using a Mendelian randomization analysis (1775 subjects with genome-wide association study) after reviewing already proven 12 hemoglobin-associated genetic polymorphisms. Results: The body mass index, paroxysmal AF, warfarin use, and baseline red cell distribution width were independently associated with anemia in patients with AF. During a 23-month follow-up (interval OR 9-48 months), the clinical AF recurrence rate was significantly higher in patients with than without anemia (log-rank p = 0.001; propensity score-matched log-rank p = 0.004). This pattern was more significant in male patients (Log-rank p < 0.001) or patients with paroxysmal AF (Log-rank p < 0.001). Anemia (hazard ratio [HR] 1.45 [1.17-1.80], p = 0.001), left atrial diameter (HR 1.03 [1.01-1.04], p < 0.001), a female sex (HR 1.17 [1.00-1.36], p = 0.047), and persistent AF (HR 1.58 [1.36-1.84], p < 0.001) were independently associated with post-AFCA clinical recurrence. In the Mendelian randomization, we could not find a significant direct causal relationship between anemia and AF recurrence at the genetic level. Conclusions: Pre-AFCA anemia is an independent predictor of post-AFCA clinical recurrence, especially in male patients, without a genetically direct causal relationship.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherElsevier Ireland-
dc.relation.isPartOfInternational Journal of Cardiology. Heart & Vasculature-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical Relationship Between Anemia and Atrial Fibrillation Recurrence After Catheter Ablation Without Genetic Background-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMin Kim-
dc.contributor.googleauthorMyunghee Hong-
dc.contributor.googleauthorJong-Youn Kim-
dc.contributor.googleauthorIn-Soo Kim-
dc.contributor.googleauthorHee Tae Yu-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorHui-Nam Pak-
dc.identifier.doi10.1016/j.ijcha.2020.100507-
dc.contributor.localIdA00840-
dc.contributor.localIdA00926-
dc.contributor.localIdA00926-
dc.contributor.localIdA01085-
dc.contributor.localIdA01085-
dc.contributor.localIdA01776-
dc.contributor.localIdA01776-
dc.contributor.localIdA02337-
dc.contributor.localIdA02337-
dc.contributor.localIdA02535-
dc.contributor.localIdA02535-
dc.contributor.localIdA02766-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ03806-
dc.identifier.eissn2352-9067-
dc.identifier.pmid32258364-
dc.subject.keywordAnemia-
dc.subject.keywordAtrial fibrillation-
dc.subject.keywordCatheter ablation-
dc.subject.keywordMendelian randomization-
dc.contributor.alternativeNameKim, In-Soo-
dc.contributor.affiliatedAuthor김인수-
dc.contributor.affiliatedAuthor김종윤-
dc.contributor.affiliatedAuthor김종윤-
dc.contributor.affiliatedAuthor김태훈-
dc.contributor.affiliatedAuthor김태훈-
dc.contributor.affiliatedAuthor박희남-
dc.contributor.affiliatedAuthor박희남-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor이문형-
dc.contributor.affiliatedAuthor이문형-
dc.contributor.affiliatedAuthor정보영-
dc.contributor.affiliatedAuthor정보영-
dc.citation.volume27-
dc.citation.startPage100507-
dc.identifier.bibliographicCitationInternational Journal of Cardiology. Heart & Vasculature, Vol.27 : 100507, 2020-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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