Lateral Onlay Grafting Using Different Combinations of Soft-Type Synthetic Block Grafts and Resorbable Collagen Membranes: An Experimental in Vivo Study

Abstract

Objectives: To observe the sequential healing of lateral onlay grafts in terms of volumetric and histological changes when using different combinations of synthetic soft-type block bone and resorbable collagen membranes.

Materials and methods: A lateral onlay graft procedure was applied at the chronic narrow alveolar ridge of the mandible in 15 beagle dogs. The groups were allocated as follows: (a) empty control; (b) onlay graft using soft-type block bone 1 (hydroxyapatite [HA]: β-tricalcium phosphate [β-TCP] = 15:85) and a non-cross-linked collagen membrane (MP-BG group); (c) onlay graft using soft-type block bone 2 (HA:β-TCP = 60:40) and a non-cross-linked collagen membrane (OC-BG group); and (d) onlay graft using soft-type block bone 1 (HA:β-TCP = 15:85) and a cross-linked collagen membrane (MP-CM group). Volumetric and histomorphometric analyses were performed at 4, 8 and 16 weeks postoperatively.

Results: No clinical complications occurred in any of the groups. The OC-BG group showed significantly larger total augmented volumes than the control and MP-BG groups after 8 and 16 weeks. The areas of new bone were significantly larger in the OC-BG group than the other groups at 16 weeks. The horizontal thickness of the augmented ridge was significantly larger in the OC-BG group than in the control group at 16 weeks.

Conclusion: The OC-BG group showed superior volume maintenance and osteogenic potential for up to 16 weeks compared to the other groups in an onlay graft model of the dog mandible despite the displacement of the bone graft.