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Skeletal Changes During Lactation and After Weaning in Osteocyte-Specific Sclerostin Overexpressed Mice

Authors
 Su Jin Lee  ;  Sun Yong Song  ;  Yumie Rhee 
Citation
 JOURNAL OF BONE AND MINERAL METABOLISM, Vol.38(2) : 172-178, 2020-03 
Journal Title
 JOURNAL OF BONE AND MINERAL METABOLISM 
ISSN
 0914-8779 
Issue Date
2020-03
Keywords
Bone ; Lactation ; Microstructure ; Sclerostin ; Weaning
Abstract
Introduction: Lactation inevitably leads to a state of rapid bone loss; however, maternal bone undergoes rapid remineralization after weaning. Sclerostin, encoded by the gene SOST, is exclusively secreted from osteocytes and plays important roles in bone remodeling. However, there are few studies about the effect of sclerostin during lactation and weaning on bone microstructures. Therefore, we conducted the study to demonstrate any possible association of sclerostin with bone metabolism and skeletal changes during lactation and after weaning. Materials and methods: We analyzed bone mineral density (BMD) by dual-energy X-ray absorptiometry at the spine and femur, bone microstructure by micro-computed tomography (μCT) at the distal and mid-shaft of the femur and biochemical markers such as sclerostin and bone turnover markers at 1 week and 3 weeks of lactation and 2 weeks post-weaning in osteocyte-specific sclerostin-overexpressed transgenic mice, and compared them with wild type. Results: Lactation significantly resulted in decreased spine and femur BMD at day 7 and day 21 of breastfeeding; specifically, cortical microstructure (cross-sectional thickness and cross-sectional area) at the mid-shaft of the femur had significantly deteriorated. At day 14 after weaning, femur BMD and cortical microstructure at the mid-shaft of the femur in both the wild and DMP-SOST mice had incompletely recovered; however, spine BMD and trabecular microstructures at the distal femur recovered in wild type mice. Conclusions: Sclerostin, secreted by osteocytes, played a role in bone loss during lactation and also in the recovery of trabecular bone compartment by activating bone formation after weaning.
Full Text
https://link.springer.com/article/10.1007%2Fs00774-019-01044-6
DOI
10.1007/s00774-019-01044-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176028
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