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Prognostic Value of Bone Marrow F-18 FDG Uptake in Patients With Advanced-Stage Diffuse Large B-Cell Lymphoma

Authors
 Jiyoung Wang  ;  Dongwoo Kim  ;  Won Jun Kang  ;  Hojin Cho 
Citation
 NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.54(1) : 28-34, 2020-02 
Journal Title
NUCLEAR MEDICINE AND MOLECULAR IMAGING
ISSN
 1869-3474 
Issue Date
2020-02
Keywords
Bone marrow involvement ; Diffuse large B-cell lymphoma ; Fluorodeoxyglucose ; Prognosis
Abstract
Purpose: We assessed prognostic implication of bone marrow uptake on baseline F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients with advanced-stage diffuse large B-cell lymphoma (DLBCL).

Methods: We retrospectively reviewed 140 patients with stage III and IV DLBCL, who underwent baseline F-18 FDG PET/CT at diagnosis. Bone marrow uptake on F-18 FDG PET/CT (BM FDG) was compared with findings on bone marrow biopsy (BMB), and patients were grouped based on these results: BMB-positive and BM FDG-positive (group 1), BMB-positive and BM FDG-negative (group 2), BMB-negative and BM FDG-positive (group 3), and BMB-negative and BM FDG-negative (group 4). The prognostic value of clinicopathologic factors and BM FDG for predicting progression-free survival (PFS) and overall survival (OS) was assessed using a Cox proportional hazards model. Differences in PFS and OS were examined by the Kaplan-Meier method.

Results: BMB was the only significant indicator in predicting PFS, and age, IPI score higher than 3, and BM FDG significantly predicted OS. Group 1 showed inferior PFS than group 2 (median PFS, 7.4 vs. 13.9 months; p = 0.04). In contrast, there was no significant difference either in PFS or OS between group 2 and group 3.

Conclusion: We showed that BM FDG-positive predicted a poorer survival in patients with advanced stage DBLCL. We also found that BMB-negative and BM FDG-positive patients had similar PFS or OS to BMB-positive and BM FDG-negative patients. Further study in a larger population is needed to clarify clinical significance of BM FDG in these patients.
Full Text
https://link.springer.com/article/10.1007/s13139-019-00630-w
DOI
10.1007/s13139-019-00630-w
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
Kim, Dongwoo(김동우) ORCID logo https://orcid.org/0000-0002-1723-604X
Wang, Jiyoung(왕지영) ORCID logo https://orcid.org/0000-0002-1275-9167
Cho, Hojin(조호진) ORCID logo https://orcid.org/0000-0002-8686-172X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175996
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