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소아 수족구병 입원 환자에 있어서 유행 주기에 따른 역학 및 임상 양상의 최근 변화

Other Titles
 Recent Changes of Epidemiological and Clinical Features of Hospitalized Childhood Hand, Foot, Mouth Disease by Epidemic Cycle 
 Newest Medical Journal (최신의학), Vol.62(2) : 36-46, 2019-12 
Journal Title
 Newest Medical Journal (최신의학) 
Issue Date
This study has done to know the recent clinical and epidemiological changes by epidemic cycle for hand, foot and mouth disease (HFMD). Methods: I collected the patient information of HFMD retrospectively who had been admitted and diagnosed clinically at the Department of Pediatrics, Yongin Severance Hospital, Yongin, Korea from January 2013 to December 2018. I divided them by epidemic cycle, investigated and compared their pidemiological and clinical features. Results: There were two cycles and the recent one was from 2016 to 2018 (group A, N=21) and the remote one from 2013 to 2015 (group B, N=47). Regarding to group A, their mean age and male to female ratio were 34.2±32.0 months old and 3.2:1. Their clinical manifestations except oral and skin involvements were fever (81.0%), poor oral intake (76.2%), cough (47.6%), rhinorrhea (42.9%). Serum total CO2 concentration was decreased in all cases (100%) and ketonuria (35.0%) was found. Serum alanine transaminase (ALT) concentration was elevated in 4 cases (19.0%). There were 4 pneumonia (19.0%), 1 febrile convulsion (4.8%), but no other neurological manifestation. The admission duration was 2.4±0.6 days . Compared to group B, group A showed different monthly occurrence peak pattern by duration and count (two months and 1 time for group A vs. one month and 2 times for group B), shorter admission duration (3.2±1.6 days for group B), higher platelet counts, more frequent cases with higher erythrocyte sedimentation rate (>20 mm/hr, 82.3% for group A vs. 50.0% for group B) and elevated ALT concentration (no case for group B, ). Conclusion: The cases are decreasing and their features have changed by epidemic cycle. Although it shows a favorable prognosis during both periods, the proportion of systemic involvement such as hepatitis and more severe inflammation is increasing.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Seung Hwan(오승환) ORCID logo https://orcid.org/0000-0003-0829-0711
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