The purpose of this investigation is to know the updated epidemic and clinical findings of hospitalized childhood cases. Methods: I collected the patient informations of HFMD retrospectively who had been diagnosed clinically and admitted at the Department of Pediatrics, Yongin Severance Hospital, Yongin, Korea from January 2013 to December 2018. I investigated their epidemiological and clinical features. Results: There were 68 cases for 6 years (40 boys and 28 girls). The mean age was 2.1±2.2 years old. Most of them (79.4%) were under 3 years old. The peak month was June (23.5%) and the most frequent season was summer. The annual occurrence tended to decrease (r=-0.81). Their clinical manifestations except oral and skin involvements were fever (86.8%), poor oral intake (85.3%), cough (48.5%), rhinorrhea (45.6%), lethargy (27.9%), sore throat(29.4%), sputum(25.0%). Serum bicarbonate concentration was decreased in almost all of them(95.6%) and ketonuria was found in 16 cases (25.4%). Serum aspartate transaminase was elevated in 33 cases (48.5%). There were 11 cases of pneumonia(16.2%), 4 pyuria(6.3%), 6 pyuria(8.8%), 1 croup (1.5%), 1 febrile convulsion (1.5%). The admission duration was 3.0±1.4 days and no patient was admitted for more than 7 days. It was longer in the cases with pneumonia (4.5±1.8 days) than others (2.7±1.1 days) (P <0.001), but other clinical parameters did not showed significant impact on it. Conclusion: HFMD predominantly occurs in younger children and early summer with a cyclic pattern and a tendency to decrease by year.Although it shows a favorable prognosis,the proportion of the cases with systemic involvement is not unremarkable and pneumonia adversely affects on prognosis, therefore physicians should be cautioned for its general clinical features. Continuous studies for its epidemiological and clinical features should be carried on to catch up the update features.