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Gamma Knife Radiosurgery for Postoperative Remnant Meningioma: Analysis of Recurrence Factors According to World Health Organization Grade

Authors
 Chang Kyu Park  ;  Na Young Jung  ;  Won Seok Chang  ;  Hyun Ho Jung  ;  Jin Woo Chang 
Citation
 WORLD NEUROSURGERY, Vol.132 : e399-e402, 2019-12 
Journal Title
 WORLD NEUROSURGERY 
ISSN
 1878-8750 
Issue Date
2019-12
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Meningeal Neoplasms / pathology* ; Meningeal Neoplasms / surgery ; Meningioma / pathology* ; Meningioma / surgery ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local / pathology* ; Neoplasm, Residual / pathology* ; Neoplasm, Residual / surgery* ; Radiosurgery* ; Retrospective Studies ; Young Adult
Keywords
Gamma Knife radiosurgery ; Malignant meningioma ; Meningioma ; Recurrence
Abstract
Objective: The effectiveness of tumor control after Gamma Knife radiosurgery (GKS) for intracranial meningioma is well established. Moreover, GKS is an alternative to reduce surgical-remnant meningioma recurrence. Nevertheless, the tumor can recur even after GKS and is associated with its histologic malignancy. We here investigated the risk factors associated with recurrence from remnant lesions after GKS, assessing recurrence patterns according to histological grades. Methods: From January 2007 to January 2017, 218 patients underwent GKS for surgical-remnant lesions. To evaluate post-GKS lesion recurrence, pre-GKS magnetic resonance images were compared with those at follow-up. We retrospectively analyzed the histologic classification of meningioma and patients' clinical characteristics (sex, age, tumor location, target volume, and prescription dose). Results: Of the 218 patients, 13 (5.9%) developed post-GKS recurrence within a mean follow-up period of 37.4 months. The recurrence patterns were as follows: adjacent to the 50% marginal-dose field (9 patients); within the 50% marginal-dose field (2 patients); and outside the field (2 patients). Six of 196 World Health Organization grade I meningioma cases, 6 of 20 grade II cases, and 1 of 2 grade III cases developed recurrence. Thus 32% of high-grade meningioma cases (grades II and III) developed recurrence during the follow-up period. Histologic grade was significantly associated (P < 0.001) with recurrence. Conclusions: The study findings indicate that the post-GKS meningioma recurrence likelihood is high when the meningioma has malignant histologic features. In addition, considering the recurrence patterns, it is important to define a precise target for GKS.
Full Text
https://www.sciencedirect.com/science/article/pii/S1878875019322922
DOI
10.1016/j.wneu.2019.08.136
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Hyun Ho(정현호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175901
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