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Factors Related to the Clinical Outcomes of Surgery for Extra-Temporal Lobe Epilepsy: Long-Term Follow-Up Results

Authors
 Yoon Ha Hwang  ;  Na Young Jung  ;  Chang Kyu Park  ;  Won Seok Chang  ;  Hyun Ho Jung  ;  Jin Woo Chang 
Citation
 WORLD NEUROSURGERY, Vol.115 : e645-e649, 2018-07 
Journal Title
 WORLD NEUROSURGERY 
ISSN
 1011-8934 
Issue Date
2018-07
MeSH
Adolescent ; Adult ; Drug Resistant Epilepsy / diagnosis* ; Drug Resistant Epilepsy / physiopathology ; Drug Resistant Epilepsy / surgery* ; Epilepsy / diagnosis ; Epilepsy / physiopathology ; Epilepsy / surgery ; Epilepsy, Temporal Lobe / diagnosis* ; Epilepsy, Temporal Lobe / physiopathology ; Epilepsy, Temporal Lobe / surgery* ; Female ; Follow-Up Studies ; Humans ; Male ; Malformations of Cortical Development / diagnosis ; Malformations of Cortical Development / physiopathology ; Malformations of Cortical Development / surgery ; Middle Aged ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Young Adult
Keywords
Extra–temporal lobe epilepsy ; Prognosis ; Surgery
Abstract
Background: Compared with temporal lobe epilepsy, the surgical outcome in extra-temporal lobe epilepsy (ETLE) is unsatisfactory. However, advances in diagnostic and surgical techniques have led to improved prognosis. This study investigated the outcomes and prognostic factors of ETLE based on long-term follow-up of patients undergoing surgical treatment for ETLE at a single institution. Methods: We retrospectively reviewed medical records of 58 patients with refractory ETLE who underwent resection between 2003 and 2015. Clinical outcome was evaluated by Engel classification. Parameters analyzed as prognostic factors were clarity of the lesion on magnetic resonance imaging, completeness of resection, and histologic diagnoses. Results: Of 58 patients (62.1%), 36 had a seizure-free state (Engel I) after surgery over a mean follow-up of 58 months. The most common pathology was cortical dysplasia (27 patients; 46.5%). In univariate analysis, only complete resection was a statistically significant prognostic factor (P = 0.001). Conclusions: Surgery is effective treatment for ETLE (79.4%, Engel I and II). Complete resection predicts more satisfactory results in patients with intractable ETLE.
Full Text
https://www.sciencedirect.com/science/article/pii/S1878875018308441
DOI
10.1016/j.wneu.2018.04.124
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Na Young(정나영)
Jung, Hyun Ho(정현호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175897
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