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The 308-nm Excimer Laser Treatment Does Not Increase the Risk of Skin Cancer in Patients With Vitiligo: A Population-Based Retrospective Cohort Study

Authors
 Jung Min Bae  ;  Sung Hye Eun  ;  Sang Ho Oh  ;  Jeong Hyun Shin  ;  Hee Young Kang  ;  Ki-Ho Kim  ;  Seung-Chul Lee  ;  Chong Won Choi 
Citation
 PIGMENT CELL & MELANOMA RESEARCH, Vol.32(5) : 714-718, 2019-09 
Journal Title
 PIGMENT CELL & MELANOMA RESEARCH 
ISSN
 1755-1471 
Issue Date
2019-09
MeSH
Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Lasers, Excimer / therapeutic use* ; Male ; Middle Aged ; Retrospective Studies ; Skin Neoplasms / prevention & control* ; Treatment Outcome ; Vitiligo / drug therapy*
Keywords
actinic keratosis ; excimer laser ; melanoma ; non-melanoma skin cancer ; skin cancer ; vitiligo
Abstract
A 308-nm excimer laser (EL) has been widely used to treat patients with localized vitiligo. However, data are rare on the influence of EL treatment on the risks of skin cancer. To evaluate the skin cancer risks after long-term EL treatment, we performed a nationwide population-based retrospective cohort study using the Korean National Health Insurance Claims Database. A total of 5,052 patients with vitiligo were classified into three groups according to the EL treatment sessions between 2009 and 2016: no, 50-99, and 100 or more EL treatments after 2-year washout period (2007 and 2008). Using multivariable Cox proportional hazard models, we found that the risks of actinic keratosis, non-melanoma skin cancers, and melanoma did not significantly differ among the groups, respectively. In conclusion, EL treatment would not increase the risks of premalignant skin lesions and skin cancers in patients with vitiligo. Based on our results, EL is likely to be a safe treatment option for patients with localized vitiligo.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/pcmr.12781
DOI
10.1111/pcmr.12781
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175885
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