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Deep Brain Stimulation: Current Challenges and Future Directions

Authors
 Andres M Lozano  ;  Nir Lipsman  ;  Hagai Bergman  ;  Peter Brown  ;  Stephan Chabardes  ;  Jin Woo Chang  ;  Keith Matthews  ;  Cameron C McIntyre  ;  Thomas E Schlaepfer  ;  Michael Schulder  ;  Yasin Temel  ;  Jens Volkmann  ;  Joachim K Krauss 
Citation
 NATURE REVIEWS NEUROLOGY, Vol.15(3) : 148-160, 2019-03 
Journal Title
 NATURE REVIEWS NEUROLOGY 
ISSN
 1759-4758 
Issue Date
2019-03
Abstract
The clinical use of deep brain stimulation (DBS) is among the most important advances in the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly measure pathological brain activity and can deliver adjustable stimulation for therapeutic effect in neurological and psychiatric disorders correlated with dysfunctional circuitry. The development of DBS has opened new opportunities to access and interrogate malfunctioning brain circuits and to test the therapeutic potential of regulating the output of these circuits in a broad range of disorders. Despite the success and rapid adoption of DBS, crucial questions remain, including which brain areas should be targeted and in which patients. This Review considers how DBS has facilitated advances in our understanding of how circuit malfunction can lead to brain disorders and outlines the key unmet challenges and future directions in the DBS field. Determining the next steps in DBS science will help to define the future role of this technology in the development of novel therapeutics for the most challenging disorders affecting the human brain.
Files in This Item:
T201906345.pdf Download
DOI
10.1038/s41582-018-0128-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175875
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