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Treatment of Medication-Related Osteonecrosis of the Jaw Around the Dental Implant With a Once-Weekly Teriparatide: A Case Report and Literature Review

Authors
 Jun-Young Kim  ;  Jin Hoo Park  ;  Hwi-Dong Jung  ;  Young-Soo Jung 
Citation
 JOURNAL OF ORAL IMPLANTOLOGY, Vol.45(5) : 403-407, 2019-10 
Journal Title
 JOURNAL OF ORAL IMPLANTOLOGY 
ISSN
 0160-6972 
Issue Date
2019-10
MeSH
Aged, 80 and over ; Bisphosphonate-Associated Osteonecrosis of the Jaw* ; Bone Density Conservation Agents* ; Bone Remodeling ; Dental Implants* ; Female ; Humans ; Teriparatide
Keywords
bisphosphonate ; implant ; osteonecrosis of the jaw ; osteoporosis ; teriparatide
Abstract
Managing medication-related osteonecrosis of the jaw (MRONJ) around a dental implant can be difficult. Although conservative treatment of MRONJ is recommended as the first-line form of management, many patients exhibit no improvement. The human recombinant parathyroid hormone teriparatide has recently been introduced for the management of MRONJ. Teriparatide is effective in the treatment of postmenopausal osteoporosis and is the only US Food and Drug Administration-approved anabolic agent that directly affects osteoblast function and contributes to bone remodeling. Herein we describe a case of MRONJ in an 85-year-old woman who was successfully treated with teriparatide. Teriparatide was administered once per week without any surgical interventions such as a sequestrectomy. Compared with most recently reported cases involving daily treatment with teriparatide, once-weekly administration of teriparatide may minimize side effects and patient discomfort. Once-weekly teriparatide application without sequestrectomy may be effective in the management of MRONJ around a dental implant.
Full Text
https://meridian.allenpress.com/joi/article-lookup/doi/10.1563/aaid-joi-D-19-00040
DOI
10.1563/aaid-joi-D-19-00040
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jun-Young(김준영) ORCID logo https://orcid.org/0000-0002-6596-6135
Jung, Young Soo(정영수) ORCID logo https://orcid.org/0000-0001-5831-6508
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175857
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